한국산 실거리나무 열매로부터 새로운 축합형탄닌 화학구조결정 및 고혈압 예방효과

• Published in: 대한본초학회지(본초분과학회지) Vol. 18; no. 4; pp. 235 - 243
• Main Authors: 안봉전, An Bong Jeon, 이진태, Lee Jin Tae, 박정미, Park Jeong Mi, 곽재훈, Gwag Jae Hun, 이진영, Lee Jin Yeong, 박찬익, Park Chan Ig, 손준호, Son Jun Ho, 임흥열, Im Heung Yeol
• Format: Journal Article
• Language: Korean
• Published: 대한본초학회 30.12.2003
• Subjects: angiotensin converting enzyme; inhibitor. anti-hypertensive ingredient; prodelphinidin B-3 3-O-gallate
• ISSN: 1229-1765

Objectives : The study was investigated decrease effiency for blood pressure of the pods of Caesalpinia sepiaria Methods : We isolated an novel compound as an angiotensin converting enzyrne(hrpertensive enzyme) inhibitor from the pods of Caedpinia sepiaria We measured inhibition rate of angiotensin converting enzyme. Results : We decided chemical structure of this new material, prodelphinidin B-3 3-0-gallate that combined with (+)-gallocatechin-3-O-gallate and (+)-gallocatechin by mechanical analysis. Effect of inhibition on the angiotensin converting enzyme was shown that B-ring, gallate compound in prodelphinidins, grown the effect of inhibition. Frodelphinidin B-3 3-0-gallate inhibited about 75.5% at 75 μmole, is shown a possibility that is used to industry. Conclusion : The pods of Chsalpinia sepiaria were expected functional agents for decreasing blood pressure at drug and food industry.