가토에서 Heparin 투여는 뇌 공기색전증으로 인한 신경학적 손상을 감소 시키는가?

• Published in: Korean journal of anesthesiology Vol. 33; no. 4; pp. 604 - 609
• Main Authors: 유건희, Keon Hee Ryu, 박철주, Cheol Joo Park, 김성년, Sung Nyeon Kim, 최종호, Jong Ho Cho, 김은성, Eun Sung Kim, 이윤기, Yoon Ki lEE, 홍영호, Young Ho Hong, 김창성, Chang Sung Kim
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.10.1997
• Subjects: air; Animals; heparin. Embolism; impairment. Pharmacology; rabbit. Brain
• ISSN: 2005-6419; 2005-7563

Background : Neurological injury after cerebral air embolism may be due to thromboinflammatory responses at sites of air-injured endothelium. Because heparin inhibits multiple thromboinflammatory processes. we hypothesized that heparin would decrease neurological impairment after cerebral air embolism. Methods : Anesthetized rabbits received either heparin (n=14) or saline(n=13), 5 minutes before air injection (150 μL/kg). Heparin was given as a 200 IU/kg bolus and followed by a constant infusion of 75 IU/kg/h for 2 hours. Equal volumes of salines were given to saline group. Two hours later, anesthesia was discontinued. Rabbits were neurologically evaluated 24 hours after air embolism. Results : Heparin group had significantly less neurological impairment at 24 hours (34 14) than saline controls(52 8) (p=0.0013). Conclusions : When given prophylactically, heparin decreases neurological impairment caused by severe cerebral arterial air embolism. (Korean J Anesthesiol 1997; 33: 604∼609)