자율신경병증을 동반한 인슐린비의존형 당뇨병환자에서 식도 및 위기능장애에 관한 고찰

• Published in: The Korean journal of medicine Vol. 49; no. 4; pp. 471 - 477
• Main Authors: 조재현, Jae Hyun Cho, 강호철, Ho Chul Kang, 선영덕, Young Duk Sun, 양승원, Seung Won Yang, 박철주, Chul Ju Park, 최은진, Eun Jin Choi, 박상선, Sang Sun Park, 이대호, Dai Ho Lee, 정민영, Min Young Chung, 이태희, Tai Hee Lee, 송호천, Ho Chun Song, 범희승, Hee Seung Beom
• Format: Journal Article
• Language: Korean
• Published: 대한내과학회 01.10.1995
• Subjects: Autonomic neuropathy; Diabetic ; Remaining radioactivity ; Gastric emptying time ( GET ) ; Esophageal transit time ( ETT ) ; Radionuclide isotope
• ISSN: 1738-9364

Objectives: This study was performed to examine the usefulness of the following measurements in evaluating the gastrointestinal motility disturbance in diabetic patients: RGR (Remaining Gastric Radioactivity), GET (Gastric Emptying Time), RER (Remaining Esophageal Radioactivity) and ETT (Esophageal Transit Time) using radianuclide isotope in a liquid diet as well as in a solid diet. Methods: Forty eight non insulin dependent diabetic patients (NIDDM) complaining of gsstrointestinal symptoms were divided into two groups: NlDDM without autonomic neuropathy (Group II, n =21) and NIDDM with autonomic neuropathy (Group III, n=27), and compared with healthy control subjects (Group I, n=51). In each group, ETT, RER, RGR and GET after taking a solid or a liquid diet were measured by the use of radionuclide iso tope. Results: 1) ETT of group III after taking a liquid diet was 24.8±2.76sec, which was significantly longer than those of group I (8.3±0.80sec) and II (8.8±0.48 sec) (p<0.001). 2) ETT of group III after taking a solid diet was 49.20±3.81sec, which was significantly longer than those of group I (18.40±2.32sec) and II (19.75±1.68sec) (p<0.001). 3) RER of group III after taking s liquid diet was 37.2±7.72%, which was significantly higher than those of group I (9.3±0.50) and II (8.3k0.48) (p<0.005). 4) RER of group III after taking a solid diet was 37.84+10.55%, which was significantly higher than those of group I (4.10±0.46%) and II(5.32±0.81 %) (p<0.005). 5) GET of group III after taking a liquid diet was 33.6±2.17min, which was significantly longer than those of group I (21.5±6.70min) and II (26.1±0.40min) (p<0.05). 6) GET of group UI after taking a solid diet was 114.2±8.03min, which was significantly longer than those of group I (61.4±3.65min) and II (60.6±5.21min) (p<0.001). Conclusion: The measurements of ETT as well as GET, using a liquid and a solid diet, are helpful for the evaluations of disorders of esophagogastric motility in patients with diabetic autonomic neuropathy.