메틸렌 블루 색소내시경과 조직학적으로 확인된 장상피화생에서 Helicobacter pylori 양성률에 대한 연구

• Published in: Taehan Sohwagi Naesigyŏng Hakhoe chi Vol. 19; no. 2; pp. 193 - 199
• Main Authors: 권선희, Sun Hee Kwon, 장영운, Young Woon Chang, 김윤화, Yoon Hwa Kim, 이정환, Jung Hwan Lee, 동석호, Seok Ho Dong, 김효종, Hyo Jong Kim, 김병호, Byung Ho Kim, 이정일, Joung Il Lee, 장린, Rin Chang
• Format: Journal Article
• Language: Korean
• Published: 대한소화기내시경학회 30.04.1999
• Subjects: Helicobacter pylori; Intestinal metaplasia
• ISSN: 1225-7001

Background/Aims: To assess the relationship between the intestinal metaplasia, Helico-bacter pylori infection, and H. pylori positivity, the difference in the type of intestinal metaplasia according to H. pylori status were examined. Methods: Chromoendoscopy by methylene blue stain method was performed to assess the diagnostic viability for the detection of intestinal metaplasia in subjects who having histologically determined intes-tinal metaplasia. Results: Intestinal metaplasia was found in 35 subjects. Of these, 21subjects (60%) were male and 14 subjects (40%) were female. Of 35 subjects, 26 subjects were H. pylori positive cases (74.3%) and 9 subjects were H. pylori negative cases (25.7%). The mean age of intestinal metaplasia subjects was 51.5 8.9 years. Of these, the mean age of H. pylori positive subjects was 49.5 8.0 years, whereas the mean age of H. pylori negative subjects was 57.2 9.2 years (p ＜0.05). On the type of intestinal metaplasia, 31 subjects showed type I (88.6%) and 4 subjects showed type II (11.4%). There was no statistical difference of intestinal metaplasia type according to H. pylori status. The diagnostic value of methylene blue chromoendoscopy in the diagnosis of intestinal metaplasia had a sensitivity of 82.4%, specificity of 100%, positive predictivevalue of 100% and negative predictive value of 75%. Conclusions: Although a causal relationship between H. pylori infection and the histogenesis of intestinal metaplasia was not proven, it is suggested that H. pylori positive cases lead to an earlier development of intestinal metaplasia than H. pylori negative cases. Therefore, it is important to assess the probability of the development of gastric carcinoma through a follow up study. (Korean J Gastrointest Endosc 19: 193 ∼199, 1999)