Halothane 및 Enflurane 마취중 부정맥을 일으키는 Epinephrine 량의 비교적 연구

• Published in: Korean journal of anesthesiology Vol. 12; no. 4; pp. 1 - 4
• Main Authors: 곽일용, II Yong Kwak, 김성덕, Seong Deok Kim
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회(구 대한마취과학회) 30.12.1979
• ISSN: 2005-6419; 2005-7563

While halothane, cyclopropane, chloroform and trichloroethylene have been clearly implicated to sensitize the myocardum ar.d increase the risk of ventricular fibrillation, newer inhalation anesthetics have shown relatively less arrhythmogenecity. Isoflurane has been suggested to be compatible with epinephrine, while controversial data suggest enflurane, an isomer of isoflurane, may or may not sensitize the myocardium, which is to be clarified by the authors study. By constant intravenous infusion using VIP pump at the rate of 2.5μg/kg/min, the dosage of epinephrine causing premature ventricular contractions was measured in ten male mongrel dogs during halothane and enflurane anesthesia. While premature ventricular contractions were observed in all dogs anesthetized with halothane, the cardiac arrhythythmia was seen in only two dogs anesthetized with enflurane. Epinephrine dosage causing premature ventricular contractions and the resultant increase in mean arterial pressure at which arrhythmias occurred were significantly higher(p< 0. 05) during enflurane anesthesia than durinh halothane anesthesiae. These results suggest that enflurane, in comparison with halothane, is reIatively less arrhythmogenic.