A comparison of Agiolax and lactulose in elderly patients with chronic constipation

In a double-blind crossover study the efficacies of Agiolax, a combination of fibre and senna pod, and lactulose were compared in 77 long-stay elderly patients with chronic constipation. Mean daily bowel frequency, stool consistency and ease of evacuation were significantly greater with Agiolax than...

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Bibliographic Details
Published inPharmacology Vol. 47 Suppl 1; p. 249
Main Authors Passmore, A P, Davies, K W, Flanagan, P G, Stoker, C, Scott, M G
Format Journal Article
LanguageEnglish
Published Switzerland 01.10.1993
Subjects
Aged
Aged, 80 and over
Cathartics - adverse effects
Cathartics - therapeutic use
Chronic Disease
Constipation - drug therapy
Constipation - physiopathology
Double-Blind Method
Drug Combinations
Female
Gastric Emptying
Gastrointestinal Motility
Humans
Lactulose - adverse effects
Lactulose - therapeutic use
Male
Plant Extracts - adverse effects
Plant Extracts - therapeutic use
Plantago
Senna Extract - adverse effects
Senna Extract - therapeutic use
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Summary:In a double-blind crossover study the efficacies of Agiolax, a combination of fibre and senna pod, and lactulose were compared in 77 long-stay elderly patients with chronic constipation. Mean daily bowel frequency, stool consistency and ease of evacuation were significantly greater with Agiolax than lactulose. The recommended dose was exceeded more frequently with lactulose than Agiolax (chi 2 = 8.38, p < 0.01). Adverse effects were not different for the 2 treatments. In long-stay elderly patients with chronic constipation Agiolax and lactulose were well tolerated, but Agiolax proved a more effective treatment.
ISSN:0031-7012
DOI:10.1159/000139865