Effect of isomers of octopamine on in vitro reactivity of vascular smooth muscle of rats

The vascular reactivity to DL-ortho-, meta-, and para-octopamine was tested in vitro in aortic smooth muscle of the rat. When reactivities were compared on a molar basis with L-phenylephrine, an alpha-adrenergic agonist, the potencies of the three isomers were: 0.7500, 0.0075 and 0.0038 times that o...

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Bibliographic Details
Published inPharmacology Vol. 21; no. 5; p. 342
Main Authors Ress, R J, Rahmani, M A, Fregly, M J, Field, F P, Williams, C M
Format Journal Article
LanguageEnglish
Published Switzerland 1980
Subjects
Animals
Aorta - drug effects
Isomerism
Male
Muscle, Smooth, Vascular - drug effects
Norepinephrine - pharmacology
Octopamine - pharmacology
Phenylephrine - pharmacology
Rats
Time Factors
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Summary:The vascular reactivity to DL-ortho-, meta-, and para-octopamine was tested in vitro in aortic smooth muscle of the rat. When reactivities were compared on a molar basis with L-phenylephrine, an alpha-adrenergic agonist, the potencies of the three isomers were: 0.7500, 0.0075 and 0.0038 times that of phenylephrine for the m-, p- and o-isomer, respectively, Thus, of the three isomers, DL-m-octopamine had the greatest alpha-adrenergic activity in vitro as it did in vivo in earlier studies. Additional studies showed L-phenylephrine to induce about one-third the vascular response induced by L-norepinephrine.
ISSN:0031-7012
DOI:10.1159/000137450