전침자극과 트레드밀운동이 허혈성 뇌졸중 백서모델의 근위축 및 BDNF 발현에 미치는 영향

• Published in: Han'guk Chŏnmun Mulli Ch'iryo Hakhoe chi = Journal of the Korean Academy of University Trained Physical Therapists Vol. 14; no. 1; pp. 1 - 10
• Main Authors: 유영대, Young Dae Yoo, 민순규, Soon Gyu Min, 김기도, Gi Do Kim, 김계엽, Gye Yeop Kim, 심재환, Jae Hwan Shim
• Format: Journal Article
• Language: Korean
• Published: 한국전문물리치료학회 31.03.2007; Korean Academy Of University Trained Physical Therapy
• Subjects: BDNF; Brain-Derived Neurotrophic Factor; Electroacupuncture; Ischemic stroke; Muscle atrophy; Treadmill exercise; 물리치료학; Treadmill exercise; Brain-Derived Neurotrophic Factor (BDNF); Muscle atrophy; Ischemic stroke; Electroacupuncture
• ISSN: 1225-8962; 2287-982X

This study was designed to examine the effects of electroacupuncture and treadmill exercise on the improvement of muscle atrophy and Brain-Derived Neurotrophic Factor (BDNF) expression in an ischemic stroke model induced by middle cerebral artery occlusion. This study selected 120 Sprangue-Dawley rats, divided them into six groups, and assigned 5 rats to each group. Experiments were conducted for 1, 3 days and 1, 8 weeks, respectively. In each group, changes in weight of muscle and relative muscle of tibialis anterior muscle, histologic observations, and BDNF expression were observed and analyzed. For the changes in muscle weight of unaffected and affected sides of tibialis anterior, muscle atrophy was expressed in an affected side 3 days after ischemic stroke was induced. There was a statistically significant difference in Group VI 1 and 8 weeks after ischemic stroke was induced, compared to Group II (p<.05). For the changes in relative muscle weight of unaffected and affected sides of tibial anterior muscle, there was significant decrease in each group 3 days after ischemic stroke was induced, compared to Group I, while there was a statistically significant increase in Group VI 1 week after ischemic stroke was induced, compared to Group II (p<.05). For neurologic exercise behavior test, Group VI generally had the highest score, compared to other groups. The results of the behavior test suggests that 8 weeks after ischemic stroke was induced, Group VI improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, thus indicating a similar state of muscle fiber and brain tissue in Group I. In immunohistochemical observations, Group 1 week showed increase in BDNF. Based on these results, electroacupuncture and treadmill exercise may improve muscle atrophy and change in BDNF expression of ischemic stroke rats and contribute to the improvement of exercise function.