콜라겐 트리펩타이드를 함유한 콜라겐 가수분해물의 피부 광노화 예방 효과

• Published in: Han'guk Sikp'um Kwahakhoe Chi = Korean Journal of Food Science and Technology Vol. 51; no. 5; pp. 466 - 472
• Main Authors: 김애향(Ae-Hyang Kim), 하민우(Min Woo Ha), 김준일(Jun Il Kim), 박철(Zhe Piao), 신용철(Yong Chul Shin), 신대근(Daekeun Shin)
• Format: Journal Article
• Language: Korean
• Published: Seoul 한국식품과학회 01.10.2019; Korean Society of Food Science & Technology
• Subjects: Aging; Aging (metallurgy); Biomarkers; Collagen; Collagenase 3; Hairless; Interstitial collagenase; Irradiation; Matrix metalloproteinase; Metalloproteinase; Skin; Supplements; Ultraviolet radiation; 식품과학; skin wrinkle; anti-photoaging; collagen tripeptides; ultraviolet B; collagen hydrolysate
• ISSN: 0367-6293; 2383-9635
• DOI: 10.9721/KJFST.2019.51.5.466

This study was conducted to investigate anti-photoaging effects of collagen hydrolysate containing collagen tripeptides (CTP) in both HaCaT cells and SKH-1 hairless mice. CTP treatment was nontoxic to HaCaT cells and improved expression of biomarkers associated with aging of skin, such as, collagen 1A, metalloproteinase (MMP)-1, and MMP-13 after subjecting mice to ultraviolet B (UVB) irradiation. In animal studies, the depth and width of wrinkles in the skin of mice were determined upon subjecting them to UVB irradiation. However, positive effects on wrinkles on the skin of mice were seen following CTP supplementation. Collagen content and density of mouse skin were restored following CTP supplementation for 14 weeks after UVB irradiation. These results were based on the effects of CTP on protein levels of collagen 1A, MMP-1, and MMP-13. Therefore, CTP might have positive effects on the number, depth, and width of wrinkles caused by UVB irradiation in SKH-1 hairless mice.