새로운 옥사졸리디논계 항균제 LCB01-0183의 항균 활성

This study was performed to analyze in vitro and in vivo activities of LCB01-0183, a new oxazolidinone, against clinical isolates of bacteria. In vitro antibacterial activity of LCB01-0183 was tested by the two fold agar dilution method. In vivo activity of LCB01-0183 was determined against systemic...

Full description

Saved in:
Bibliographic Details
Published inYaghag-hoi-ji Vol. 57; no. 2; pp. 95 - 100
Main Authors 이현희, 정성지, 정지웅, 조영락, 김용주, 곽진환
Format Journal Article
LanguageKorean
Published The Pharmaceutical Society Of Korea 2013
대한약학회
Subjects
약학
LCB01-0183
antibacterial activity
oxazolidinone
time-kill
MIC
Online AccessGet full text

Cover

More Information
Summary:This study was performed to analyze in vitro and in vivo activities of LCB01-0183, a new oxazolidinone, against clinical isolates of bacteria. In vitro antibacterial activity of LCB01-0183 was tested by the two fold agar dilution method. In vivo activity of LCB01-0183 was determined against systemic infections in mice. LCB01-0183 showed most potent activity among the test compounds against clinical isolates of Gram-positive bacteria. Furthermore, the protective activity of LCB01-0183 was very effective against systemic infections in mice by oral or subcutaneous administration. In time kill study, LCB01-0183 showed a bacteriostatic activity during 24 hours. LCB01-0183 had potent in vitro and in vivo activity against Gram-positive bacteria including drug-resistant strains.
Bibliography:KISTI1.1003/JNL.JAKO201319953221847
G704-000392.2013.57.2.007
ISSN:0377-9556
2383-9457