주의력결핍 과잉행동장애 아동에서 α-2A 아드레날린 수용체 유전자의 MspI 유전자 다형성에 따른 메칠페니데이트 치료 전후 뇌관류 비교

• Published in: Soa--chʻŏngsonyŏn chŏngsin ŭihak = Journal of child & adolescent psychiatry Vol. 24; no. 1; pp. 21 - 27
• Main Authors: 박수빈(Subin Park), 배정훈(Jeong-Hoon Bae), 김재원(Jae-Won Kim), 양영희(Young-Hui Yang), 오승민(Seungmin Oh), 홍순범(Soon-Beom Hong), 박민현(Min-Heyon Park), 김붕년(Boong-Nyun Kim), 신민섭(Min-Sup Shin), 유희정(Hee-Jeong Yoo), 조수철(Soo-Churl Cho)
• Format: Journal Article
• Language: Korean
• Published: 대한소아청소년정신의학회 2013
• Subjects: Attention-Deficit Hyperactivity Disorder; 주의력결핍 과잉행동장애; Pharmacogenetics; 단일광자 방출 컴퓨터단층촬영; Single-Photon Emission Computed Tomography; ADRA2A; 약물유전학
• ISSN: 1225-729X; 2233-9183

Objectives : Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD. Methods : Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated. Results : No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype. Conclusion : Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.