Basic and clinical study of laryngeal allergy
A series of animal studies were performed to investigate the histopathological and pathophysiological characteristics of laryngeal allergy. First, guinea pigs were sensitized by ovalbumin. The histological sections were made and stained with hematoxylin-eosin, toluidine blue and IgE. Allergic reacti...
Saved in:
| Published in | OTOLOGIA FUKUOKA Vol. 41; no. 5Supplement2; pp. 871 - 877 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
JIBI TO RINSHO KAI
20.11.1995
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0447-7227 2185-1034 |
| DOI | 10.11334/jibi1954.41.5Supplement2_871 |
Cover
| Abstract | A series of animal studies were performed to investigate the histopathological and pathophysiological characteristics of laryngeal allergy. First, guinea pigs were sensitized by ovalbumin. The histological sections were made and stained with hematoxylin-eosin, toluidine blue and IgE. Allergic reactions were observed in the laryngeal mucosa of these sections. Secondly, nebulized particles of Pyoktanin blue were inhales under quiet respiration and the degree of staining in the respiratory tract was visually inspected after removal of the laynx. Laryngeal surface and trachea were stained blue suggesting the possible. contact of the antigen to the laryngeal mucosa. Thirdly, the effect of the histamine on mucosa blood flow of the larynx was evaluated with the spectrophotometric analyzer. The results revealed that the O2 saturation decreasedand the hemoglobin concentration increased. These phenomena accounted for the clinical findings of the allergic mucosa, being edematous and pale in colour. To detect latent laryngeal allergy among patients who complained of the lump sensation in the throat, a screening prescription consisting of an anti-allergic drug was administered to them. The complaines of 68% of the patients were improved and some of them showed disappearance of the edema in the arytenoid region. Possble diagnostic methods for laryngeal allergy including a provocation test were discussed. It was considered clinically important to establish criteria for laryngeal allergy. |
|---|---|
| AbstractList | A series of animal studies were performed to investigate the histopathological and pathophysiological characteristics of laryngeal allergy. First, guinea pigs were sensitized by ovalbumin. The histological sections were made and stained with hematoxylin-eosin, toluidine blue and IgE. Allergic reactions were observed in the laryngeal mucosa of these sections. Secondly, nebulized particles of Pyoktanin blue were inhales under quiet respiration and the degree of staining in the respiratory tract was visually inspected after removal of the laynx. Laryngeal surface and trachea were stained blue suggesting the possible. contact of the antigen to the laryngeal mucosa. Thirdly, the effect of the histamine on mucosa blood flow of the larynx was evaluated with the spectrophotometric analyzer. The results revealed that the O2 saturation decreasedand the hemoglobin concentration increased. These phenomena accounted for the clinical findings of the allergic mucosa, being edematous and pale in colour. To detect latent laryngeal allergy among patients who complained of the lump sensation in the throat, a screening prescription consisting of an anti-allergic drug was administered to them. The complaines of 68% of the patients were improved and some of them showed disappearance of the edema in the arytenoid region. Possble diagnostic methods for laryngeal allergy including a provocation test were discussed. It was considered clinically important to establish criteria for laryngeal allergy.
喉頭アレルギーの病態については不明な点が多い. 喉頭は解剖学的にアプローチ困難な部位であり, しかも呼吸にとって重要な役割を果たしている. このことにより局所におけるアレルギーの検査が容易でなく, 実地臨床の場で診断に苦慮することも多い.われわれは実験動物を用いた喉頭アレルギーモデルを作製した. さらに抗原粒子の喉頭粘膜への付着の可能性の有無およびヒスタミンの喉頭粘膜血流量に及ぼす影響について検討した. その結果動物において喉頭にアレルギー反応が存在しうるという結論を得たため臨床的な検討を行った. 臨床的に喉頭アレルギーが疑われる患者に対し, 抗アレルギー剤の投与を行い, 症状, 所見の改善を認めた. また一例において誘発反応を行い, 組織学的にアレルギー反応をとらえた. これらの結果を踏まえて喉頭アレルギーの存在を確認するとともに, 簡便に診断できるクライテリアの確立が喉頭アレルギー診療に寄与すると思われた. A series of animal studies were performed to investigate the histopathological and pathophysiological characteristics of laryngeal allergy. First, guinea pigs were sensitized by ovalbumin. The histological sections were made and stained with hematoxylin-eosin, toluidine blue and IgE. Allergic reactions were observed in the laryngeal mucosa of these sections. Secondly, nebulized particles of Pyoktanin blue were inhales under quiet respiration and the degree of staining in the respiratory tract was visually inspected after removal of the laynx. Laryngeal surface and trachea were stained blue suggesting the possible. contact of the antigen to the laryngeal mucosa. Thirdly, the effect of the histamine on mucosa blood flow of the larynx was evaluated with the spectrophotometric analyzer. The results revealed that the O2 saturation decreasedand the hemoglobin concentration increased. These phenomena accounted for the clinical findings of the allergic mucosa, being edematous and pale in colour. To detect latent laryngeal allergy among patients who complained of the lump sensation in the throat, a screening prescription consisting of an anti-allergic drug was administered to them. The complaines of 68% of the patients were improved and some of them showed disappearance of the edema in the arytenoid region. Possble diagnostic methods for laryngeal allergy including a provocation test were discussed. It was considered clinically important to establish criteria for laryngeal allergy. |
| Author | TAKEUCHI, Shin-ichi ISHITANI, Yasuo YAMASHITA, Toshiyuki YAMAGUCHI, Mikio TAMURA, Koichi HORI, Yoji TAKEDA, Naoya TACHIBANA, Fumitoshi ABE, Koji KONDO, Akio KIMOTO, Koji NUNOMURA, Shinsaku SHIMADA, Takaaki KASHIMA, Kenji KOIKE, Yasuo KINOSHITA, Michiko |
| Author_FL | 武田 直也 阿部 晃治 立花 文寿 竹内 紳一 布村 進作 木下 道子 堀 洋二 記本 晃治 田村 公一 山口 幹夫 嶋田 高明 小池 靖夫 山下 利幸 近藤 昭男 石谷 保夫 加島 健司 |
| Author_FL_xml | – sequence: 1 fullname: 山下 利幸 – sequence: 2 fullname: 山口 幹夫 – sequence: 3 fullname: 武田 直也 – sequence: 4 fullname: 嶋田 高明 – sequence: 5 fullname: 堀 洋二 – sequence: 6 fullname: 立花 文寿 – sequence: 7 fullname: 記本 晃治 – sequence: 8 fullname: 竹内 紳一 – sequence: 9 fullname: 加島 健司 – sequence: 10 fullname: 木下 道子 – sequence: 11 fullname: 阿部 晃治 – sequence: 12 fullname: 田村 公一 – sequence: 13 fullname: 石谷 保夫 – sequence: 14 fullname: 小池 靖夫 – sequence: 15 fullname: 布村 進作 – sequence: 16 fullname: 近藤 昭男 |
| Author_xml | – sequence: 1 fullname: TAMURA, Koichi organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: KIMOTO, Koji organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: KINOSHITA, Michiko organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: TAKEDA, Naoya organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: KOIKE, Yasuo organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: YAMAGUCHI, Mikio organization: Yamaguchi ENT clinic – sequence: 1 fullname: SHIMADA, Takaaki organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: NUNOMURA, Shinsaku organization: Department of Otolaryngology, Komatsushima Red Cross Hospital – sequence: 1 fullname: ISHITANI, Yasuo organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: TAKEUCHI, Shin-ichi organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: KASHIMA, Kenji organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: KONDO, Akio organization: Department of Otolaryngology, Taijyukai Kaisei Hospital – sequence: 1 fullname: YAMASHITA, Toshiyuki organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: TACHIBANA, Fumitoshi organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: HORI, Yoji organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan – sequence: 1 fullname: ABE, Koji organization: Department of Otolaryngology, The University of Tokushima, School of Medicine, Tokushima 770, Japan |
| BackLink | https://cir.nii.ac.jp/crid/1390282680475609216$$DView record in CiNii |
| BookMark | eNpVkE1LAzEQhoNUsNb-hz3ocWsmX5sctWgVKh7sPWSzkzUlTcvu9tB_70pV8DLDDA8vL881meR9RkLugC4AOBf321hHMFIsBCzkx_FwSLjDPDCrK7ggUwZalkC5mJApFaIqK8aqKzLv-1hTyigVTPMpKR9dH33hclP4FHP0LhX9cGxOxT4UyXWn3OL4cilh155uyGVwqcf5z56RzfPTZvlSrt9Xr8uHdbk1RpU8qIYbQWXl0dWS-dorDCC0oY0EqmvmG-WY5AIVolSCBxe0ROYaHbgCPiO359gco_XxewI3lGmmNBWVVNQwUCP2dsa2_eBatIcu7sbG1nVD9AntryErwP4zNN6jpD_Of7rOYuZfAJ1mMg |
| ContentType | Journal Article |
| Copyright | JIBI TO RINSHO KAI |
| Copyright_xml | – notice: JIBI TO RINSHO KAI |
| DBID | RYH |
| DOI | 10.11334/jibi1954.41.5Supplement2_871 |
| DatabaseName | CiNii Complete |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | 喉頭アレルギーの総合的研究 |
| DocumentTitle_FL | 喉頭アレルギーの総合的研究 |
| EISSN | 2185-1034 |
| EndPage | 877 |
| ExternalDocumentID | 50005298864 article_jibi1954_41_5Supplement2_41_871_article_char_en |
| GroupedDBID | ABJNI ACGFS ALMA_UNASSIGNED_HOLDINGS JSF KQ8 RJT RYH |
| ID | FETCH-LOGICAL-j996-3f6d394057ceab52cbc6ef14890d5108b2cd6a2534e6ee5643faf85e2ad8f3613 |
| ISSN | 0447-7227 |
| IngestDate | Fri Jun 27 00:58:50 EDT 2025 Wed Sep 03 06:07:43 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 5Supplement2 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-j996-3f6d394057ceab52cbc6ef14890d5108b2cd6a2534e6ee5643faf85e2ad8f3613 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/jibi1954/41/5Supplement2/41_871/_article/-char/en |
| PageCount | 7 |
| ParticipantIDs | nii_cinii_1390282680475609216 jstage_primary_article_jibi1954_41_5Supplement2_41_871_article_char_en |
| PublicationCentury | 1900 |
| PublicationDate | 1995/11/20 |
| PublicationDateYYYYMMDD | 1995-11-20 |
| PublicationDate_xml | – month: 11 year: 1995 text: 1995/11/20 day: 20 |
| PublicationDecade | 1990 |
| PublicationTitle | OTOLOGIA FUKUOKA |
| PublicationTitleAlternate | jibi to rinsho |
| PublicationTitle_FL | 耳鼻と臨床 耳鼻 OTOLOGIA FUKUOKA |
| PublicationYear | 1995 |
| Publisher | JIBI TO RINSHO KAI |
| Publisher_xml | – name: JIBI TO RINSHO KAI |
| References | 23) 山口幹夫他: 喉頭アレルギーにおける喉頭所見, 日気食会報42 3: 259-263, 1991. 17) 堀洋二他: MASTを用いた喉頭アレルギー疑症例の検討. 第10回喉頭アレルギー研究会記録集 (抄録): 5-8, 1992. 9) 山下利幸他: アレルギー診断上の問題点. 第3回喉頭アレルギー研究会記録集 (抄録): 14-21, 1989. 2) Brodnitz FS: Allergy of the larynx. ORL Clin North Am 4 (3): 579-582, 1971. 10) 山下利幸他: 病理組織学的に確診し得た喉頭アレルギーの症例. 第4回喉頭アレルギー研究会記録集 (抄録): 2-7, 1979. 1) Williams RI: Allergic laryngitis. Ann Otol 81: 558-565, 1972. 3) MOses P: The Voice of Neurosis: pp 121. Grune & Stratton, New York, 1954. 19) 堀洋二他: 喉頭アレルギーに対する抗アレルギー剤投与の試み. 第12回喉頭アレルギー研究会記録集 (抄録): 11-15, 1993. 12) 山口幹夫他: ヒスタミンのモルモット喉頭粘膜血流量に及ぼす作用 (第二報), 第5回喉頭アレルギー研究会記録集 (抄録): 6-7, 1990. 22) 小池靖夫他: 咽喉頭異常感の数量化について. 耳鼻臨床補23: 46-50, 1988. 24) 山下利幸他: 病理組織学的に確診し得た喉頭アレルギーの症例. 喉頭1 2: 102-104, 1989. 7) 山口幹夫他: 喉頭アレルギーが疑われた2症例. 第2回咽頭アレルギー研究会記録集 (抄録): 3, 1988. 16) 山口幹夫: 抗原暴露の観点よりみた喉頭の特徴. サテライトシンポジウム, 喉頭アレルギー記録集: 7-8, 1992. 20) 阿部晃治他: 抗アレルギー剤が無効であった喉頭アレルギー疑診例の検討. 第13回喉頭アレルギー研究会記録集 (抄録): 3-6, 1994. 4) Paparella MM: Unusual foreign body of trachea and intrinsic bee sting of larynx. J Laryng 78: 89-92, 1964. 25) 小池靖夫他: 咽喉頭異常感症に対する診断的治療. 耳鼻臨床72: 1499-1506, 1979. 8) 山下利幸他: 喉頭炎におけるアレルギー関与. 第2回喉頭アレルギー研究会記録集 (抄録): 4, 1988. 13) 近藤昭男他: 実験動物における喉頭アレルギー作成の試み. 第6回喉頭アレルギー研究会記録集 (抄録): 2, 1990. 11) 山口幹夫他: ヒスタミンのモルモット喉頭粘膜血流量に及ぼす作用. 第4回喉頭アレルギー研究会記録集 (抄録): 8-9, 1989. 14) 山口幹夫他: 抗アレルギー剤投与後, 披裂部浮腫の軽減を認めた一症例, 第6回喉頭アレルギー研究会記録集 (抄録): 10, 1990. 21) 山口幹夫他: ヒスタミンの喉頭粘膜血液量に及ぼす作用. 耳鼻臨床83 12: 1865-1871, 1990. 18) 嶋田高明他: 喉頭擦過細胞診の試み. 第11回喉頭アレルギー研究会記録集 (抄録): 2-6, 1993. 6) 切替一郎・野村恭也: 新耳鼻咽喉化学 (第七版): 492, 南山堂 5) Wolf IJ: Allergic factors in the etiology of spasmodic croup and laryngo-tracheitis. Am Allergy 24: 79-82, 1966. 15) 近藤昭男他: 実験動物における喉頭アレルギー作成の試み (第二報). |
| References_xml | – reference: 12) 山口幹夫他: ヒスタミンのモルモット喉頭粘膜血流量に及ぼす作用 (第二報), 第5回喉頭アレルギー研究会記録集 (抄録): 6-7, 1990. – reference: 10) 山下利幸他: 病理組織学的に確診し得た喉頭アレルギーの症例. 第4回喉頭アレルギー研究会記録集 (抄録): 2-7, 1979. – reference: 20) 阿部晃治他: 抗アレルギー剤が無効であった喉頭アレルギー疑診例の検討. 第13回喉頭アレルギー研究会記録集 (抄録): 3-6, 1994. – reference: 21) 山口幹夫他: ヒスタミンの喉頭粘膜血液量に及ぼす作用. 耳鼻臨床83 12: 1865-1871, 1990. – reference: 24) 山下利幸他: 病理組織学的に確診し得た喉頭アレルギーの症例. 喉頭1 2: 102-104, 1989. – reference: 5) Wolf IJ: Allergic factors in the etiology of spasmodic croup and laryngo-tracheitis. Am Allergy 24: 79-82, 1966. – reference: 4) Paparella MM: Unusual foreign body of trachea and intrinsic bee sting of larynx. J Laryng 78: 89-92, 1964. – reference: 7) 山口幹夫他: 喉頭アレルギーが疑われた2症例. 第2回咽頭アレルギー研究会記録集 (抄録): 3, 1988. – reference: 19) 堀洋二他: 喉頭アレルギーに対する抗アレルギー剤投与の試み. 第12回喉頭アレルギー研究会記録集 (抄録): 11-15, 1993. – reference: 2) Brodnitz FS: Allergy of the larynx. ORL Clin North Am 4 (3): 579-582, 1971. – reference: 14) 山口幹夫他: 抗アレルギー剤投与後, 披裂部浮腫の軽減を認めた一症例, 第6回喉頭アレルギー研究会記録集 (抄録): 10, 1990. – reference: 8) 山下利幸他: 喉頭炎におけるアレルギー関与. 第2回喉頭アレルギー研究会記録集 (抄録): 4, 1988. – reference: 1) Williams RI: Allergic laryngitis. Ann Otol 81: 558-565, 1972. – reference: 3) MOses P: The Voice of Neurosis: pp 121. Grune & Stratton, New York, 1954. – reference: 18) 嶋田高明他: 喉頭擦過細胞診の試み. 第11回喉頭アレルギー研究会記録集 (抄録): 2-6, 1993. – reference: 6) 切替一郎・野村恭也: 新耳鼻咽喉化学 (第七版): 492, 南山堂 – reference: 17) 堀洋二他: MASTを用いた喉頭アレルギー疑症例の検討. 第10回喉頭アレルギー研究会記録集 (抄録): 5-8, 1992. – reference: 11) 山口幹夫他: ヒスタミンのモルモット喉頭粘膜血流量に及ぼす作用. 第4回喉頭アレルギー研究会記録集 (抄録): 8-9, 1989. – reference: 23) 山口幹夫他: 喉頭アレルギーにおける喉頭所見, 日気食会報42 3: 259-263, 1991. – reference: 15) 近藤昭男他: 実験動物における喉頭アレルギー作成の試み (第二報). – reference: 9) 山下利幸他: アレルギー診断上の問題点. 第3回喉頭アレルギー研究会記録集 (抄録): 14-21, 1989. – reference: 13) 近藤昭男他: 実験動物における喉頭アレルギー作成の試み. 第6回喉頭アレルギー研究会記録集 (抄録): 2, 1990. – reference: 22) 小池靖夫他: 咽喉頭異常感の数量化について. 耳鼻臨床補23: 46-50, 1988. – reference: 16) 山口幹夫: 抗原暴露の観点よりみた喉頭の特徴. サテライトシンポジウム, 喉頭アレルギー記録集: 7-8, 1992. – reference: 25) 小池靖夫他: 咽喉頭異常感症に対する診断的治療. 耳鼻臨床72: 1499-1506, 1979. |
| SSID | ssib002004283 ssj0000400194 ssib005879669 ssib058493091 |
| Score | 1.2927258 |
| Snippet | A series of animal studies were performed to investigate the histopathological and pathophysiological characteristics of laryngeal allergy. First, guinea pigs... |
| SourceID | nii jstage |
| SourceType | Publisher |
| StartPage | 871 |
| SubjectTerms | 喉頭アレルギー 抗アレルギー剤 披裂部浮腫 肥満細胞 脱穎粒 |
| Title | Basic and clinical study of laryngeal allergy |
| URI | https://www.jstage.jst.go.jp/article/jibi1954/41/5Supplement2/41_871/_article/-char/en https://cir.nii.ac.jp/crid/1390282680475609216 |
| Volume | 41 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | jibi to rinsho, 1995/11/20, Vol.41(5Supplement2), pp.871-877 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb5wwELWaVKp6qVK1VdMmFYf0hNiyxubjSNJsoShZtWGl9ISMsRN2pd0quzlsfn3GxnxEipq2FwsMssAzPN5g5g1CRxEAI3GZ61AumQNOETmMARgKLrlPJRAUqdU-z_1kRr5f0su-3JHOLtmUI373aF7J_1gV-sCuKkv2HyzbDQodsA32hRYsDO1f2fiYrY3cap_g2IpEQ8S6XV4p2WBVLeXm6sHy7TTXRRBiezLLZtOss-IvgOCLJM1jO1-tr-vt7aIeHvo2O0lS-6xeND9v6Yg_zk6_xgDSq20H8DDCWQydOVswZkaoTKYdVRl22O1BPz1O7Xxq_0zPL5KpnRlx6gaaCAmcADdZ_S2ONgJWxl-oLkqqv3DiAT6GTb2V7lUbPI7inkcUjNdlrQTpRmQ8out-vKIb5YFQNm2WLcPQJzvoOQ4CvWyf_RiEUzpCHOBRGEC019E54GKR5xrtIP0mJ4oBawWy9oZfoM_tFX750_UBoZkDvVe6DTvLuh5wlnwPvTLBhhU3nvMaPZuzN8jRXmOB11it11jaa6yVtDqvsYzXvEX55DQ_SRxTNMOZq__JPelXqtg9DbhgJcW85L6QEPNGbgXwG5aYVz7D1CPCF4ICH5VMhlRgVoXSA273Du0uV0vxHlmCBIJFwNAjVSUZkJ6r4KLCzCNcVcLYR5PmFovfjTBKYR6Eop2YgoyLoSOofZib7jyVWAjP8T46hCkqeK1aiEjUZwA_dEkAbDzCY__DE8c_ope9_x6g3c3NrTgEqrgpP2n73wNFFV1c |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Basic+and+clinical+study+of+laryngeal+allergy&rft.jtitle=OTOLOGIA+FUKUOKA&rft.au=YAMASHITA+Toshiyuki&rft.au=YAMAGUCHI+Mikio&rft.au=TAKEDA+Naoya&rft.au=SHIMADA+Takaaki&rft.date=1995-11-20&rft.pub=JIBI+TO+RINSHO+KAI&rft.issn=0447-7227&rft.volume=41&rft.issue=5Supplement2&rft.spage=871&rft.epage=877&rft_id=info:doi/10.11334%2Fjibi1954.41.5supplement2_871&rft.externalDocID=50005298864 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0447-7227&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0447-7227&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0447-7227&client=summon |