Basic and clinical study of laryngeal allergy

• Published in: OTOLOGIA FUKUOKA Vol. 41; no. 5Supplement2; pp. 871 - 877
• Main Authors: TAMURA, Koichi, KIMOTO, Koji, KINOSHITA, Michiko, TAKEDA, Naoya, KOIKE, Yasuo, YAMAGUCHI, Mikio, SHIMADA, Takaaki, NUNOMURA, Shinsaku, ISHITANI, Yasuo, TAKEUCHI, Shin-ichi, KASHIMA, Kenji, KONDO, Akio, YAMASHITA, Toshiyuki, TACHIBANA, Fumitoshi, HORI, Yoji, ABE, Koji
• Format: Journal Article
• Language: Japanese
• Published: JIBI TO RINSHO KAI 20.11.1995
• Subjects: 喉頭アレルギー; 抗アレルギー剤; 披裂部浮腫; 肥満細胞; 脱穎粒
• ISSN: 0447-7227; 2185-1034
• DOI: 10.11334/jibi1954.41.5Supplement2_871

A series of animal studies were performed to investigate the histopathological and pathophysiological characteristics of laryngeal allergy. First, guinea pigs were sensitized by ovalbumin. The histological sections were made and stained with hematoxylin-eosin, toluidine blue and IgE. Allergic reactions were observed in the laryngeal mucosa of these sections. Secondly, nebulized particles of Pyoktanin blue were inhales under quiet respiration and the degree of staining in the respiratory tract was visually inspected after removal of the laynx. Laryngeal surface and trachea were stained blue suggesting the possible. contact of the antigen to the laryngeal mucosa. Thirdly, the effect of the histamine on mucosa blood flow of the larynx was evaluated with the spectrophotometric analyzer. The results revealed that the O2 saturation decreasedand the hemoglobin concentration increased. These phenomena accounted for the clinical findings of the allergic mucosa, being edematous and pale in colour. To detect latent laryngeal allergy among patients who complained of the lump sensation in the throat, a screening prescription consisting of an anti-allergic drug was administered to them. The complaines of 68% of the patients were improved and some of them showed disappearance of the edema in the arytenoid region. Possble diagnostic methods for laryngeal allergy including a provocation test were discussed. It was considered clinically important to establish criteria for laryngeal allergy.