Changes over an 8-year period in Streptococcus pyogenes emm types in pharyngeal isolates from non-invasive infection patients at a pediatric facility

Streptococcus pyogenes, or Group A Streptococcus (GAS), is one of the most common pathogens of bacterial infection in children. GAS can cause such non-serious and non-invasive diseases as pharyngitis and skin infections, as well as serious and invasive diseases like streptococcal toxic shock syndrom...

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Published inJournal of Nippon Medical School p. JNMS.2020_87-502
Main Authors Okabe, Toshinari, Norose, Yoshihiko, Hida, Masatoshi, Takeda, Sachiyo, Takase, Masato, Suzuki, Yoshiko, Ohkuni, Hisashi
Format Journal Article
LanguageEnglish
Published Japan The Medical Association of Nippon Medical School 31.01.2020
Subjects
children
dominant emm
pharyngitis
Streptococcus pyogenes
Streptococcus pyogenes
pharyngitis
children
dominant emm
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Summary:Streptococcus pyogenes, or Group A Streptococcus (GAS), is one of the most common pathogens of bacterial infection in children. GAS can cause such non-serious and non-invasive diseases as pharyngitis and skin infections, as well as serious and invasive diseases like streptococcal toxic shock syndrome. One of the factors that make GAS pathogenic is the type-specific M protein found on the cell surface. In 2008, we examined GAS strains isolated from patients with non-invasive infections at our hospital to analyze the emm types and their characteristics. The present study was conducted 8 years later for comparison.Methods:The 23 study subjects were in patients or out patients at Nippon Medical School's Tama Nagayama Hospital between 2016 and 2017. A pharyngeal swab were taken from each subjects. Genes encording M proteins were amplified by polymerase chain reaction.Results:The emm type analysis identified emm1 in 11 of the 23 strains and emm12 in 4. The 3 GGS strains carried the M-like protein genes.Conclusions:In our earlier report, the predominant emm type was emm12, while in the current study, emm1 was the most common. The current study also identified 3 strains of Group G Streptococcus (GGS) among the isolates, which carried a stg245, stg6795, and stg840 gene, respectively. One GAS strain was found to carry stg485, a gene typically associated with GGS rather than GAS.
ISSN:1345-4676
1347-3409
DOI:10.1272/jnms.JNMS.2020_87-502