MILBEMYCINS α11, α12, α13, α14 and α15: A NEW FAMILY OF MILBEMYCINS FROM Streptomyces hygroscopicus subsp. aureolacrimosus TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 produces a new family of milbemycins, named milbemycins α11, β12, α13, α14 and α15, together with other milbemycins. Their structures are 3-methyl-2-butenoyloxy and 3-methylbutyroyloxy derivatives at C-4a of milbemycins A3 and A4, or 3-met...

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Published inJournal of antibiotics Vol. 46; no. 9; pp. 1364 - 1371
Main Authors TAKAHASHI, SHUJI, MIYAOKA, HIROKO, TANAKA, KEIJI, ENOKITA, RYUZO, OKAZAKI, TAKAO
Format Journal Article
LanguageEnglish
Published Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 25.09.1993
Japan Antibiotics Research Association
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Streptomyces hygroscopicus
Streptomycetaceae
Molecular structure
Taxonomy
Macrolide
Biological activity
Actinomycetales
Acaricide
Antibiotic
Parasiticid
Bacteria
Actinomycetes
Physicochemical properties
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Summary:Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 produces a new family of milbemycins, named milbemycins α11, β12, α13, α14 and α15, together with other milbemycins. Their structures are 3-methyl-2-butenoyloxy and 3-methylbutyroyloxy derivatives at C-4a of milbemycins A3 and A4, or 3-methyl-2-pentenoyloxy derivative at C-4a of milbemycin A3, respectively. Milbemycin α14, 3-methyl-2-butenoyloxy derivative, especially possesses a potent acaricidal activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1364