The Effects of Electron-Rich Water Administration on Oxidative Stress and Antioxidant Potential in Cats with Chronic Kidney Disease（Stage 1）

• Published in: Journal of Animal Clinical Medicine Vol. 27; no. 4; pp. 157 - 162
• Main Authors: SAKURAI, Reina, KONNO, Yoshinobu, ONUMA, Masahiro, UCHIDA, Naohiro, IGUCHI, Aiko, KOBAYASHI, Saori, YAMASAKI, Masahiro, SATO, Reeko
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Clinical Veterinary Medicine 15.01.2019
• Subjects: cat; chronic kidney disease; electron-rich water
• ISSN: 1344-6991; 1881-1574
• DOI: 10.11252/dobutsurinshoigaku.27.157

In human chronic kidney disease (CKD), the production of reactive oxygen species (ROS) is increased and the antioxidant ability of the body is decreased. Even in cats with CKD, the oxidative damage due to ROS production in the kidney tissue causes renal tubular and interstitial fibrosis. In this study, we investigated the effect of electron-rich water supplied to cats with early-stage CKD, by observing changes in the levels of blood oxidation (d-ROM) and antioxidant ability (BAP) markers. The level of the antioxidant ability marker significantly increased in the control group due to the 1-month electron-rich water supply, and the CKD group also showed an increasing tendency, although there was no significant difference. The levels of the blood serum oxidation marker showed decreasing tendency, although there were no significant defferences between before and after electron-rich water supply in both groups. It is suggested that the supply of electron-rich water may contribute to alleviation of oxidative stress and activation of antioxidant capacity in cats.