Drug-induced Nephritis in Two Cats

• Published in: Journal of Animal Clinical Medicine Vol. 21; no. 3; pp. 109 - 116
• Main Authors: TAKENAKA, Masahiko, SATO, Reeko, YAMANE, Yoshihisa
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Clinical Veterinary Medicine 20.10.2012
• Subjects: cats; drug-induced nephritis; overdose
• ISSN: 1344-6991; 1881-1574
• DOI: 10.11252/dobutsurinshoigaku.21.109

Two cats that demonstrated increase of the urinary protein and the urinary cast, as well as the decline of urinary concentration function, during the treatment of the bacterial cystitis and after the lumbricidal and depulization were diagnosed with the renal failure medicamentosa. In Case 1, the selection of a wrong antibiotic and its overdose was suspected as the cause of the symptoms, where the tubular failure was observed.? Dosing adequate an antibiotic and adequate volume resulted in the cure. In Case 2, dosing of the parasiticide to a juvenile animal reached the intoxicating dose level, and the glomerulus and tublointerstitial failure were strongly observed.? Steroid was used for the treatment and showed marked effect, but the failure of urinary concentration function remained. Further, as a background to the renal failure medicamentosa, it is thought that in Case 1, the volume of antibiotic dosed increased with each new hospital, and in Case 2 overdose to a juvenile animal with immature the renal function was suspected. Clinical vets must consider the appropriate amount of dose with care.