The Bactericidal Effects of Ozone Gel

• Published in: The Journal of Showa University Dental Society Vol. 24; no. 2; pp. 103 - 109
• Main Authors: NIINOMI, Kazuhito, KANAISHI, Azusa, SHIBA, Akihiko, TSUKASAKI, Hiroaki, IWASA, Fuminori, HIRATA, Tomohide
• Format: Journal Article
• Language: Japanese
• Published: Showa University Dental Society 30.06.2004
• Subjects: bactericidal effects; electrolyzed gel hard type; glycerin; microorganism; ozone gel
• ISSN: 0285-922X; 2186-5396
• DOI: 10.11516/dentalmedres1981.24.103

For exploring the dental application of ozone gel, the bactericidal potency was compared between the freshly purified ozone gel containing 3 different ozone concentrations and the electrolyzed gel hard-type, and between the ozone gel immediately after purification and the ozone gel storaged for 2 months after purification at room temperature. The ozone gel containing 10 ppm ozone showed a bactericidal effect on E. coli, aeruginosa, S. mutans, B. subtilis, C. albicans all about 5 bacterial strains immediately after addition and, among them, only C. albicans was decreased to be lower than the detection limit, and even after 6 h of reaction, only E. coli, K. pneumoniae, P. aeruginosa, S. mutans, S. aureus, C. albicans all about 6 strains became lower than the detection limit. This bactericidal potency was slightly stronger than that of electrolyzed gel hard-type. The gel containing 100 ppm ozone showed a greater bactericidal effect than the 10 ppm ozone gel, and the 1000 ppm ozone gel reduced E. coli, K. pneumoniae, P. aeruginosa, S. mutans, S. aureus, MRSA, S. epidermidis, C. albicans all about 8 bacterial strains to be lower than the detection limit immediately after addition, except for B. subtilis. The ozone gel immediately after purification and the ozone gel storaged at room temperature for 2 months after purification showed similar bactericidal effects on E. coli and S. aureus regardless of reaction time. These results suggest that the ozone gel can be used widely and is clinically useful as well, because it has instantaneous and persistent bactericidal effects.