Clinicopathological significance of ki-67 antibody labeling index for patients with squamous cell carcinoma of the esophagus

• Published in: Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 72; no. 6; pp. 1347 - 1354
• Main Authors: TABATA, Koki, MIYATA, Kanji, YUASA, Norihiro, TAKEUCHI, Eiji, GOTO, Yasutomo, MIYAKE, Hideo, NAGAI, Hidemasa, KOBAYASHI, Yoichiro, KAJIURA, Dai, ITO, Masafumi
• Format: Journal Article
• Language: Japanese
• Published: Japan Surgical Association 2011
• Subjects: carcinoma of the esophagus; Ki–67 antibody labeling index; lymph node metastasis; MIB–1; prognostic factor
• ISSN: 1345-2843; 1882-5133
• DOI: 10.3919/jjsa.72.1347

Background : Ki-67 antibody labeling index (MIB-1) is an indicator of cell proliferation, and has been investigated in carcinoma of the lung and breast. However, its correlation with clinicopathological significance and prognosis in squamous cell carcinoma (SCC) of the esophagus has not been determined. Patients and Methods : Twenty-five patients who underwent potentially curative resection for SCC of the esophagus in the hospital between 2006 and 2008 were enrolled in this study. Patients who had preoperative radio-and/or chemotherapy were excluded. Clinicopathological factors, prognosis of the patients and correlation between the MIB-1 of the primary tumors and the maximum standardized uptake values (max-SUV) in fluorodeoxyglucose positron emission tomography (FDG-PET) were investigated. Results : The mean MIB-1 was 42.3 % (range, 13.0-73.2 %), and it was significantly correlated with lymph node metastasis (p=0.002) and pathological stage (p=0.007). Patients with high MIB-1 (more than 40 %) showed a significantly poor disease-free survival compared with those with low MIB-1 (less than 40%) (p=0.035). Weak correlation was found between the MIB-1 and max-SUV (p=0.051). Conclusion : The MIB-1 has a significant correlation with lymphatic extension and pathological stage, and can be a prognostic parameter. MaxSUV might be a predictive factor of prognosis.