Pregnancy and soluble VEGF receptor 1(sFlt-1)

Hypertensive disorders of pregnancy (HDP) are still life-threatening diseases.However, the pathogenesis of HDP has progressed rapidly in the last 20 years. Recently ‘Two Step Theory’ has been proposed and widely accepted. In the theory, soluble VEGF receptor 1(sFlt-1) plays crucial roles. Thus far,...

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Published inReproductive Immunology and Biology Vol. 34; pp. 9 - 16
Main Authors Kumasawa, Keiichi, Iriyama, Takayuki, Nagamatsu, Takeshi, Osuga, Yutaka, Fujii, Tomoyuki
Format Journal Article
LanguageJapanese
Published Japan Society for Immunology of Reproduction 2019
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Abstract Hypertensive disorders of pregnancy (HDP) are still life-threatening diseases.However, the pathogenesis of HDP has progressed rapidly in the last 20 years. Recently ‘Two Step Theory’ has been proposed and widely accepted. In the theory, soluble VEGF receptor 1(sFlt-1) plays crucial roles. Thus far, many HDP model animals have been exploited and accelerated the HDP research. In the research of HDP, many Japanese researchers have occupied important parts in both in vitro and in vivo experiments, in addition to clinical discoveries. In this review, we explain about the relations between HDP and sFlt-1, and then introduce mainly two kinds of model mice of HDP by our groups.
AbstractList Hypertensive disorders of pregnancy (HDP) are still life-threatening diseases.However, the pathogenesis of HDP has progressed rapidly in the last 20 years. Recently ‘Two Step Theory’ has been proposed and widely accepted. In the theory, soluble VEGF receptor 1(sFlt-1) plays crucial roles. Thus far, many HDP model animals have been exploited and accelerated the HDP research. In the research of HDP, many Japanese researchers have occupied important parts in both in vitro and in vivo experiments, in addition to clinical discoveries. In this review, we explain about the relations between HDP and sFlt-1, and then introduce mainly two kinds of model mice of HDP by our groups.
Author Kumasawa, Keiichi
Fujii, Tomoyuki
Osuga, Yutaka
Nagamatsu, Takeshi
Iriyama, Takayuki
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  organization: Department of Animal Science, The University of Tokyo Hospital
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  fullname: Iriyama, Takayuki
  organization: Department of Animal Science, The University of Tokyo Hospital
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  fullname: Nagamatsu, Takeshi
  organization: Department of Animal Science, The University of Tokyo Hospital
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  fullname: Osuga, Yutaka
  organization: Department of Animal Science, The University of Tokyo Hospital
– sequence: 5
  fullname: Fujii, Tomoyuki
  organization: Department of Animal Science, The University of Tokyo Hospital
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