Pregnancy and soluble VEGF receptor 1(sFlt-1)

Hypertensive disorders of pregnancy (HDP) are still life-threatening diseases.However, the pathogenesis of HDP has progressed rapidly in the last 20 years. Recently ‘Two Step Theory’ has been proposed and widely accepted. In the theory, soluble VEGF receptor 1(sFlt-1) plays crucial roles. Thus far,...

Full description

Saved in:
Bibliographic Details
Published inReproductive Immunology and Biology Vol. 34; pp. 9 - 16
Main Authors Kumasawa, Keiichi, Iriyama, Takayuki, Nagamatsu, Takeshi, Osuga, Yutaka, Fujii, Tomoyuki
Format Journal Article
LanguageJapanese
Published Japan Society for Immunology of Reproduction 2019
Online AccessGet full text

Cover

More Information
Summary:Hypertensive disorders of pregnancy (HDP) are still life-threatening diseases.However, the pathogenesis of HDP has progressed rapidly in the last 20 years. Recently ‘Two Step Theory’ has been proposed and widely accepted. In the theory, soluble VEGF receptor 1(sFlt-1) plays crucial roles. Thus far, many HDP model animals have been exploited and accelerated the HDP research. In the research of HDP, many Japanese researchers have occupied important parts in both in vitro and in vivo experiments, in addition to clinical discoveries. In this review, we explain about the relations between HDP and sFlt-1, and then introduce mainly two kinds of model mice of HDP by our groups.
ISSN:1881-607X
1881-7211
DOI:10.3192/jsirib.34.9