Ability of Pasteurella canis isolated from host animals and human patients in Japan to invade human keratinocytes

We examined human keratinocyte cell invasion ability (CIA) of Pasteurella canis from 17 animals and 13 humans with relationships between CIA and host/genotypic traits. We designated CIA higher than isolate mean as high-frequency and that lower than mean as low-frequency. Repetitive element-based fin...

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Bibliographic Details
Published inJapanese Journal of Veterinary Research Vol. 71; no. 4; pp. 121 - 129
Main Authors Yoshida Haruno, Maeda Takahiro, Goto Mieko, Tsuyuki Yuzo, Shizuno Kenichi, Takahashi Takashi
Format Journal Article
LanguageEnglish
Published Japanese Journal of Veterinary Research Editorial Committee 29.03.2024
JJVR編集委員会
Subjects
Cell invasion ability
Human keratinocyte
Pasteurella canis
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Summary:We examined human keratinocyte cell invasion ability (CIA) of Pasteurella canis from 17 animals and 13 humans with relationships between CIA and host/genotypic traits. We designated CIA higher than isolate mean as high-frequency and that lower than mean as low-frequency. Repetitive element-based fingerprinting dendrograms were constructed; virulence-associated genes were clustered in phylogenetic trees. High-frequency CIA was observed in 9 isolates; low-frequency CIA in 21. No relationships were observed between high-frequency CIA and host/source. Dendrograms showed no associations between high-frequency CIA/host and different clades (A–1/–2; B–1/–2/–3). Trees with ptfA–ompA alleles showed no associations between high-frequency CIA/host and different clusters (1/2; 1/2/3). Our observations suggest CIA assessment feasibility without relationships between high-frequency CIA and host/genotypic traits.
ISSN:0047-1917
2758-447X
DOI:10.57494/jjvr.71.4_121