Clinical Evaluation of Secondary Grafting of a Mixture of Hydroxyapatite and Autogenous Particulate Cancellous Bone and Marrow in the Alveolar Cleft

• Published in: Journal of Japanese Cleft Palate Association Vol. 25; no. 3; pp. 215 - 223
• Main Authors: SASAGURI, Masaaki, SUZUKI, Akira, OHISHI, Masamichi, OGATA, Katsuya, NAKAMURA, Norifumi, HONDA, Yasuo, NAKASIMA, Akihiko
• Format: Journal Article
• Language: Japanese
• Published: Japanese Cleft Palate Association 31.10.2000
• Subjects: bone resorption; cleft lip and palate; hydroxyapatite; mixed grafting; secondary bone grafting; ハイドロキシアパタイト; 二次的骨移植術; 口唇口蓋裂; 混合移植; 骨吸収
• ISSN: 0386-5185; 2186-5701
• DOI: 10.11224/cleftpalate1976.25.3_215

The purpose of this study was to evaluate the effectiveness of mixing hydroxyapatite granules (HA) with autogenous particulate cancellous bone and marrow (PCBM) in secondary alveolar bone grafting of cleft patients. The subjects consisted of 42 patients who received grafting of only PCBM (group 5), and 30 patients who received grafting of the mixture of PCBM and HA (group M), at the First Department of Oral and Maxillofacial Surgery, Kyushu University Dental Hospital, from 1987 to 1996. All of the patients studied were over 13 years old, because HA mixture-grafting is applied only to adolescent patients in our clinic. Serial radiographs were taken and evaluated before, just after, and more than 6months after the bone grafting. Postoperative resorption of transplanted bone, the change of interdental alveolar height, and clinical complications were compared between the S and M groups. Postoperative resorption of transplanted bone in group S was revealed to be slight in 53.1%, moderate in 32.6%, and severe in 14.3%, while the resorption in group M was slight in 71.4%and moderate in 28.6%. No severe resorption was observed in group M. The interdental alveolar height tended to be maintained at a more satisfactoly level in group M than in group 5, postoperatively. Namely, postoperative resorption of transplanted bone was found to b e less in group M than in group S. However, postoperative complications, such as dehiscence of the surgical wound and exposure of the grafted materials, were seen more often in group M than in group S. In conclusion, grafting the mixture of PCBM and HA was effective in preventing postoperative resorption of transplanted alveolar bone in adolescent cleft patients.