The Effects of M-protein Fraction of Hemolytic Streptococci on Embryonic Heart in the Rat : THE 9th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE

Wistar rats were administered M-protein fraction (MP) of group A type 12 hemolytic streptococci on day 9 of gestation. When 9 mg/kg of MP was injected, the incidence of malformations was 11.8%, and the incidence of cardiovascular malformations was 7.9%. The main malformations were ventricular septal...

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Published inJAPANESE CIRCULATION JOURNAL Vol. 49; no. 12; pp. 1265 - 1267
Main Authors MIYATA, KOICHIRO, JITOSHO, TAMOTSU, TAKESUE, TETSUO, MUNAKATA, SHUZO, ONO, SEIGO, YAMAMOTO, EIJI, KAWAKAMI, KIYOSHI, TERAWAKI, TAMOTSU
Format Journal Article
LanguageEnglish
Published The Japanese Circulation Society 20.12.1985
Subjects
Cardiovasucular malformations
Experimental teratology
M-protein of hemolytic streptococci
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Summary:Wistar rats were administered M-protein fraction (MP) of group A type 12 hemolytic streptococci on day 9 of gestation. When 9 mg/kg of MP was injected, the incidence of malformations was 11.8%, and the incidence of cardiovascular malformations was 7.9%. The main malformations were ventricular septal defect, microphthalmia, and hydrocephaly. Light and electron microscopic studies revealed no myocarditis nor endocarditis in either the maternal or fetal heart. Fluorescent antibody technique demonstrated no immunological cross-reaction between MP and rat heart tissue. the results suggest that MP is slightly teratogenic in the rat.
ISSN:0047-1828
1347-4839
DOI:10.1253/jcj.49.1265