Severe Masculinization of Urogenital Organs with Hypospadias in a Freemartin Holstein Calf

A freemartin of Holstein calf (7 months old) accompanied with penile hypospadias was clinically investigated and a pair of testis-like tissue was extracted from the subcutaneous thigh. Sex chromosomal analyses showed XX/XY chimeras in the blood, whereas the XX female type was present in the kidney a...

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Published inJournal of the Japan Veterinary Medical Association Vol. 64; no. 6; pp. 461 - 463
Main Authors SASAKURA, Harumi, HATANAKA, Midori, NIBE, Kazumi, HANEDA, Shingo, KITAHARA, Go, KAMIMURA, Shunichi
Format Journal Article
LanguageJapanese
Published Japan Veterinary Medical Association 20.06.2011
Subjects
freemartin
hypospadias
severe masculinization
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Summary:A freemartin of Holstein calf (7 months old) accompanied with penile hypospadias was clinically investigated and a pair of testis-like tissue was extracted from the subcutaneous thigh. Sex chromosomal analyses showed XX/XY chimeras in the blood, whereas the XX female type was present in the kidney and spleen. Pathological examination revealed the marked spongy body of the penis, prostate gland, and vesicular gland, whereas the female gonad and müllerian duct remained as rudimentary funiculi. These findings suggested that the calf was a freemartin with hypospadias and ectopic testicles in a morphological anomaly of the urinary tracts with severe masculinization.
ISSN:0446-6454
2186-0211
DOI:10.12935/jvma.64.461