A Case of Severe Autoimmune Hepatitis that was Treated Successfully with Steroid Therapy

A 56-year-old woman was admitted to our hospital due to liver dysfunction with epigastralgia and jaundice. Her laboratory data showed AST: 731 IU/L, ALT: 839 IU/L, T-B: 7.0 mg/dl, PT: 57%, ANA: ·640, and IgG: 1444 mg/dl. Liver biopsy findings and laboratory data were consistent with severe autoimmun...

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Bibliographic Details
Published inJournal of Nihon University Medical Association Vol. 77; no. 1; pp. 45 - 50
Main Authors Arima, Shuhei, Fujikawa, Hirotoshi, Endo, Takako, Ouchi, Kotoyo, Masuda, Ai, Fujii, Tetsuro, Tsutsumi, Natsuko, Uno, Akitake, Tsujimura, Ryusuke, Nemoto, Norimichi, Miura, Takao, Matsuok, Shunichi, Moriyama, Mitsuhiko
Format Journal Article
LanguageJapanese
Published NIHON UNIVERSITY MEDICAL ASSOCIATION 01.02.2018
Subjects
autoimmune hepatitis
severe autoimmune hepatitis with acute presentation
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Summary:A 56-year-old woman was admitted to our hospital due to liver dysfunction with epigastralgia and jaundice. Her laboratory data showed AST: 731 IU/L, ALT: 839 IU/L, T-B: 7.0 mg/dl, PT: 57%, ANA: ·640, and IgG: 1444 mg/dl. Liver biopsy findings and laboratory data were consistent with severe autoimmune hepatitis with acute presentation. Therefore, we started steroid therapy from the 8th hospital day, and she exhibited a benign course. Severe autoimmune hepatitis with acute presentation may develop into a more severe course and liver failure in the absence of treatment. If clinically autoimmune hepatitis is suspected, liver biopsy and initiation of steroid therapy as soon as possible are important in determining the convalescence of the patient.
ISSN:0029-0424
1884-0779
DOI:10.4264/numa.77.1_45