Lignified Materials as Potential Medicinal Resources.III. : Diversity of Biological Activity and Possible Molecular Species Involved

Diverse biological activities of hot-water and alkali extracts of lignified materials were reviewed and the molecular species involved are discussed. Materials tested included pine cone of Pinus parviflora SIEB. et ZUCC., wood chips of slash pine, Douglas fir, and tallow wood, and two basidiocarps,...

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Published inChemical and Pharmaceutical Bulletin Vol. 38; no. 11; pp. 3031 - 3034
Main Authors OH-HARA, Toshinari, KAWAZOE, Yutaka, SAKAGAMI, Hiroshi
Format Journal Article
LanguageEnglish
Published The Pharmaceutical Society of Japan 25.11.1990
Subjects
antibacterial antiviral
antitumor
basidiocarp
Douglas fir
immunopotentiation
lignified material
lignin
pine cone
slash pine
tallow wood
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Summary:Diverse biological activities of hot-water and alkali extracts of lignified materials were reviewed and the molecular species involved are discussed. Materials tested included pine cone of Pinus parviflora SIEB. et ZUCC., wood chips of slash pine, Douglas fir, and tallow wood, and two basidiocarps, in addition to their partially degraded preparations and commercial lingnins. As a tentative conclusion, the lignin structure of these extracts mights be responsible for the potent stimulation of granulocytic cell iodination, inhibition of viral infection and/or proliferation in vitro, and inactivation of viral ribonucleic acid (RNA)-dependent RNA polymerase and (adenosine diphosphate-ribose)n glycohydrolase. Other activities displayed by some of these extracts, such as antibacterial and antitumor activities, induction of hemolytic plaque-forming-cells in mice, and stimulation of deoxyribonucleic acid synthesis of isolated splenocytes, remain to be investigated.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.38.3031