The Significance of Hyperinsulinemia as a Predictive Factor for the Development of Hypertension Result from an 11-Year Follow-up Study

• Published in: Journal of the Japanese Association for Cerebro-cardiovascular Disease Control Vol. 28; no. 3; pp. 188 - 196
• Main Authors: Tsuruta, Makoto, Hashimoto, Ryuichi, Adachi, Hisashi, Tashiro, Hiromi, Nomura, Gakuii, Toshima, Hironori
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Association for Cerebro-cardiovascular Disease Control 01.02.1994
• Subjects: follow-up study; hyperinsulinemia; hypertension; insulin resistance
• ISSN: 0914-7284
• DOI: 10.11381/jjcdp1974.28.188

Insulin resistance and/or hyperinsulinemia induces an increase in renal Na+/water reabsorption and overactivity of the sympathetic nervous system, and whether this condition has a role as an important factor in the development of hypertension is a question, the accumulation of longitudial epidemiologic data is indispensable. An 11-year follow-up study was performed and results analyzed by multiple logistic regression analysis to study the association of insulin levels to the development of hypertension. Results are as follows : 1) Insulin concentration at 120 minutes after a 50 gram oral glucose loading showed a significant correlation with diastolic blood pressure at the entry examination. However, other parameters, ie, insulin concentrations at preload, 30, 60, and 180 minutes postload and the ratios of insulin : glucose levels, did not show significant correlations with systolic and diastolic blood pressure. 2) The Log transformed insulin concentration at preload, 60 miniutes, and summed values ; and the ratios of preload and area of insulin : glucose at the entry examination correlated significantly with systolic blood pressures at the follow-up examination. Both insulin concentration at preload, 60, and 120 minutes and summed values ; and the ratios of preload, summed values, and area of insulin : glucose were shown to have significant correlations with diastolic blood pressures. 3) Insulin levels at preload and 180 miniutes, the preload ratio of insulin : glucose, insulinogenic index and uric acid were statistically significant in predicting future hypertension, even after adjusting for age, sex, and systolic blood pressure at entry. In conclusion, insulin resistance and/or hyperinsulinemia was found to be strongly associated with future hypertension.