Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environment in Biological Systems

A combination of a direct liquid extraction using a small volume solvent and the electrospray ionization, is distinguished by its ability to rapid measurement of complex chemical components in biological samples and to visualize their distribution in a tissue section. In this review, the development...

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Bibliographic Details
Published inJournal of the Mass Spectrometry Society of Japan Vol. 68; no. 5; pp. 59 - 74
Main Author Otsuka, Yoichi
Format Journal Article
LanguageJapanese
Published Tokyo The Mass Spectrometry Society of Japan 01.10.2020
Japan Science and Technology Agency
Subjects
Acceleration
Biological properties
Chemical reactions
Ionization
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Summary:A combination of a direct liquid extraction using a small volume solvent and the electrospray ionization, is distinguished by its ability to rapid measurement of complex chemical components in biological samples and to visualize their distribution in a tissue section. In this review, the development of techniques and their application to biological research, which has been emerged since the early 2000s, is presented. In addition, an overview of ESI, the ion suppression of the mixture, and the acceleration of the specific chemical reaction in the charged droplet are presented. The future expectation for visualizing the multimolecular environment in biological systems is discussed.
ISSN:1340-8097
1880-4225
DOI:10.5702/massspec.20-106