Evaluation of prulifloxacin in the treatment of tonsillitis, pharyngolaryngitis and suppurative sialadenitis

• Published in: jibi to rinsho Vol. 43; no. 3; pp. 353 - 365
• Main Authors: BABA, Shunkichi, MIYAMOTO, Naoya, ICHIKAWA, Ginichiro, YAMAKAWA, Takuya, NAKAMURA, Miyako, ITABASHI, Takatsugu, ISHII, Tetsuo, TAKAYAMA, Mikiko, YOSHIHARA, Toshio, SAKAMOTO, Yutaka, SAKAI, Makoto, SHINKAWA, Atsushi, KIMURA, Hideshige, MIYAKE, Hirosato, SATO, Mutsumi, TAKAHASHI, Hideaki, OGATA, Tetsuro, YAMAZAKI, Mitsuyo, YOKOTA, Akira, ITO, Hiromi, MOTAI, Hisato, MORIBE, Kazuho, KOBAYASHI, Takehiro, MATSUNAGA, Toru, KUBO, Takeshi, OCHIAI, Kaoru, KAWASAKI, Yoshiaki, ISHIDA, Minoru, MATSUMOTO, Tatsuji, SATO, Shinji, OZAKI, Masayoshi, ASAI, Hideyo, NOIRI, Teruhisa, HASEGAWA, Satoshi, HARADA, Yasuo, YAJIN, Koji, HIRAKAWA, Katsuhiro, TAKUMIDA, Masaya, KOBAYASHI, Yuko, TAKEBAYASHI, Shubun, SEKITANI, Toru, TAKAHASHI, Masahiro, ENDO, Shiro, MOGI, Goro, KAWAUCHI, Hideyuki, UEYAMA, Shigehiro, TANAKA, Takahiro, OHYAMA, Masaru, FURUTA, Shigeru, MATSUZAKI, Tsutomu, FUKUSHIMA, Yasuhiro, SAKAMOTO, Kunihiko, HIROTA, Joji, MURANO, Kenzo
• Format: Journal Article
• Language: Japanese
• Published: JIBI TO RINSHO KAI 20.05.1997
• Subjects: prulifloxacin; UFX
• ISSN: 0447-7227; 2185-1034
• DOI: 10.11334/jibi1954.43.3_353

After orally administering 200mg of prulifloxacin, the concentrations of UFX (an active metabolite of PUFX) were found to range from 1.10 to 1.79μg/g in the palatine tonsillar tissue at 60 to 300 minutes and 1.23 to 4.13μg/g in the salivary gland tissue at 70 to 120 minutes, while the penetration ratios were 0.50 to 4.37 in the palatine tonsillar tissue. The clinical efficacy rates were 85% for tonsillitis, 75% for pharyngolaryngitis, 67% for suppurative sialadenitis at doses ranging from 200 to 600mg daily of PUFX. Regarding bacteriological efficacy, the eradication rates were 90% for tonsillitis and 80% for other diseases. As for the bacteriological response, the eradication rate was 92% in cases of tonsillitis. Adverse reactions were observed in 3 cases including 1 case each of eruption, nausea and loose stools, and all such reactions disappeared either during or after treatment. Abnormal changes in the laboratory findings were observed in 3 cases including an increase of eosinophiles in 2, and an elevation of total bilirubin in 1.