A clinical evaluation of ritipenem acoxil in paranasal sinusitis

• Published in: jibi to rinsho Vol. 42; no. 3; pp. 288 - 302
• Main Authors: OYAMA, Masaru, MATSUZAKI, Tsutomu, MIYAZAKI, Yasuhiro, ITABASHI, Takatsugu, ICHIKAWA, Ginichiro, NISHIYA, Masahiro, WADA, Masashi, ONISHI, Shinjirou, MIYAKE, Hirosato, SAKAI, Makoto, SHINKAWA, Atsushi, KIMURA, Hideshige, SAKAMOTO, Yutaka, BABA, Shunkichi, MIYAMOTO, Naoya, HOJO, Satoaki, KOBAYASHI, Takehiro, YOKOTA, Akira, ITO, Hiromi, KATO, Shinji, SHIMADA, Junichiro, KASASHIMA, Tetsuya, MATSUNAGA, Toru, HARADA, Tamotsu, OKUMURA, Shinichi, MISHIRO, Yasuo, ITO, Mahito, SAWADA, Toru, FUJII, Kazutoshi, SASAKI, Ryoji, HAGA, Minoru, FUKAZAWA, Keijirou, HARADA, Yasuo, SUZUKI, Mamoru, HIRAKAWA, Katsuhiro, TSUDA, Tetsuya, KOBAYASHI, Yuko, KAKI, Ototaka, SEKITANI, Toru, MIURA, Masako, HIRATA, Tetsuyasu, KANESADA, Keiko, MORIYA, Keiji, YANO, Hiromi, TSURUMARU, Hiroshi, HARAGUCHI, Kaneaki, NISHIZONO, Hirofumi, FUKAMI, Kozo, WATANABE, Soiku
• Format: Journal Article
• Language: Japanese
• Published: JIBI TO RINSHO KAI 20.05.1996
• Subjects: RIPM-AC; ritipenema coxil
• ISSN: 0447-7227; 2185-1034
• DOI: 10.11334/jibi1954.42.3_288

Ritipenem acoxil (RIPM-AC) was clinically evaluated in 61 patients with sinusitis and the following results were obtained: 1) In the 51 patients in whom clinical efficacy of the drug was evaluated, the efficacy rate was 96% for acute sinusitis, 76% for acute exacerbations of chronic sinusitis, 63% for chronic sinusitis, and 84% for all patients. 2) The eradication rate of the isolated bacteria was 91% for Gram-positive bacteria, 100% for gram-negative bacteria, and 94% for all isolates. 3) The improvement rate (the percentage of patients who showed at least a mild improvements) of the X-ray findings was 69%. 4) Side effects were noted in 2 (3%) of 59 patients, and abnomal laboratory findings M1 (3%) of 30 patients, but none were of any particular clinical significance. 5) The safety rate was 95% (56/59). 6) The usefulness rate was 83% (43/52). Based on these findings RIPM-AC is thus considered to be highly useful for the treatment of sinusitis.