Factors Related to Implementation Rate of Cancer Rehabilitation in Cervical Cancer Patients Undergoing Concurrent Chemo-radiotherapy

• Published in: Physical Therapy Japan Vol. 49; no. 1; pp. 34 - 42
• Main Authors: HARA, Mizuho, HIROTA, Keisuke, YAMASHITA, Youko, KOYA, Shunji, ICHIKAWA, Hiromi, KAI, Shiho, SOEDA, Emi, KUWANO, Saki, TASAKI, Kazuto, HASHIDA, Ryuki, KAWANO, Kouichirou, MATSUSE, Hiroo
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Physical Therapy 2022
• Subjects: Cervical cancer; Concurrent chemoradiotherapy; Implementation rate of cancer rehabilitation; Sarcopenia
• ISSN: 0289-3770; 2189-602X
• DOI: 10.15063/rigaku.12087

Objective: Concurrent chemo-radiotherapy (CCRT) is the standard treatment for cervical cancer, however, several adverse events, such as fatigue, make it difficult to implement cancer rehabilitation (CR). This study aimed to investigate the implementation rate of CR and the risk factors of low CR implementation during CCRT in patients with cervical cancer.Methods: We enrolled 17 patients with cervical cancer. The CR implementation rate was calculated from the number of days of CR implementation in the CR implementation period. The background factors, body composition, physical function, and biochemical examinations before CCRT were compared. The independent factors and profiles associated with cancer rehabilitation implementation were evaluated by decision-tree analysis. We examined the CR of each factor derived from the decision-tree analysis using ANOVA analysis and Tukey's multiple comparison test.Results: The median implementation rate of CR during the CCRT period was 55%. In the decision-tree analysis, CS-5 was selected as the initial split, and the patients with CS-5≥7.3 sec, 75% of all the patients, showed a low implementation rate. Furthermore, in a patient with CS-5≥7.3 sec, grip strength was selected as the second split. All patients with < 22.5 kg of grip strength showed a low implementation rate. In addition, old age, slow CS-5, low grip strength, and presence of sarcopenia were the characteristics of the low implementation rate group.Conclusions: We demonstrated that, older people, low physical function, low muscle strength were associated with a low rate of CR during CCRT in cervical cancer.