Two cases of globus sensation which was resistant to proton pump inhibitor treatment could be cured with comprehensive treatment including life style changing and combination drug therapy

• Published in: jibi to rinsho Vol. 50; no. 2; pp. 165 - 170
• Main Authors: MATSUBARA, Hidetoshi, TAMURA, Hiroki, TERADA, Masahiko, MITUNAMI, Kenichi, OWAKI, Narihiro, KATAOKA, Kenichi, KATAOKA, Hideyuki
• Format: Journal Article
• Language: Japanese
• Published: JIBI TO RINSHO KAI 20.03.2004
• Subjects: gastroesophageal reflux disease
• ISSN: 0447-7227; 2185-1034
• DOI: 10.11334/jibi1954.50.2_165

When glubus sensation which is resistant to proton pump inhibitor treatment, it is very hardly to determine that it is related to gastroesophageal reflux disease. In Japan it has barely been recognized that the presence of resistance to proton pump inhibitor treatment and slowly responder to vtreatment. In two cases who were resistant to 15mg lansoprazole, their globus symptoms were relieved with both of life style modification and combination therapy, specifically 20mg rabeprazole, 15mg mosapride and 48cc Maalox. Especially in one case her globus sensation had been relieving so slowly that it took almost one year until healing it. Our self-administered symptom diary was a powerful tool for its convenience and to evaluate symptoms objectively in out-patient unit. To evaluate their symptom correctly and objectively were useful not only for fair treatment response determination but also for improvement of life style. Those cases suggested that in some cases close-up evaluation of symptom and strong long-span medical therapy were required, when treating globus sensation as gastroesophageal reflux disease.