Target Screening Analysis of Pesticides in Drinking Water by Tandem Quadrupole LC-MS/MS Using Triggered MRM

• Published in: ENVIRONMENTAL SCIENCE Vol. 35; no. 2; pp. 34 - 49
• Main Authors: FURUKAWA, Koji, HASHIMOTO, Makoto, KOBAYASHI, Tamami, TAKINO, Masahiko
• Format: Journal Article
• Language: Japanese
• Published: SOCIETY OF ENVIRONMENTAL SCIENCE, JAPAN 31.03.2022
• Subjects: drinking water; LC-MS/MS; pesticides; Screening analysis; trigger MRM
• ISSN: 0915-0048; 1884-5029
• DOI: 10.11353/sesj.35.34

We have developed a target screening method based on quadrupole LC-MS/MS using the triggered MRM mode for the rapid and comprehensive detection of pesticides in drinking water. Among the 201 types of pesticides and metabolites, 91 types had a lower limit of quantification of 5 ng/L, and 46 types had a lower limit of quantification of 10 ng/L. In addition, we conducted an additional recovery test (100 ng/L; n＝5 parallel test, 5 times) in drinking water within 41 days after creating the database for screening analysis. The accuracy was found to lie between 70％ and 130％ for 164 types of pesticides and metabolites. The purity of 170 types of pesticides and metabolites, out of the 171 types, was in the range of 50–200％, which was originally set in this study as development target value of the screening method. The parallel precision was less than 30％ for all the 171 types of pesticides, and the indoor precision was less than 35％ for 170 of the 171 types of pesticides. The validation results suggest that this screening method can be effectively employed for drinking water.