Regulation of osteoclast differentiation by β-glucan mediated by dectin-1 recognition and pharmacological application

• Published in: ORAL THERAPEUTICS AND PHARMACOLOGY Vol. 41; no. 1; pp. 11 - 18
• Main Author: ARIYOSHI, WATARU
• Format: Journal Article
• Language: Japanese
• Published: JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY 2022; 日本歯科薬物療法学会
• Subjects: dectin-1; osteoclast; pattern recognition receptor; β-glucan; β-グルカン; デクチン-1; パターン認識受容体; 破骨細胞
• ISSN: 0288-1012; 1884-4928
• DOI: 10.11263/jsotp.22.02

Coordinated co-stimulatory signals mediated by several immunoreceptors are important for the regulation of osteoclast differentiation. Dectin-1 is one of the pattern recognition receptors of β-glucan and is expressed on the surface of hematopoietic osteoclast precursor cells. In this review, we discuss the biological effects of β-glucans on bone-resorbing osteoclasts. Several β-glucans negatively regulate osteoclast differentiation by binding to dectin-1. Furthermore, we demonstrated the possibility of β-glucan as a candidate of osteoclast-targeting gene delivery system. Future studies concerning the relationship between the β-glucan structure and its biological effects on osteoclast are required for the development of novel pharmacological treatment for bone-related diseases.