Prior administration of oral rehydration solution promotes gastric emptying of enteral formula
Purpose: We investigated the effect of prior administration of clear fluids (oral rehydration solution and mineral water) on gastric emptying of enteral formula in healthy subjects as compared with non-consumption of clear fluids. Clear fluids were administered before feeding enteral formula. Method...
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| Published in | Jomyaku Keicho Eiyo Vol. 27; no. 2; pp. 731 - 737 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society for Parenteral and Enteral Nutrition
2012
日本静脈経腸栄養学会 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1344-4980 1881-3623 |
| DOI | 10.11244/jjspen.27.731 |
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| Abstract | Purpose: We investigated the effect of prior administration of clear fluids (oral rehydration solution and mineral water) on gastric emptying of enteral formula in healthy subjects as compared with non-consumption of clear fluids. Clear fluids were administered before feeding enteral formula. Methods: Seven healthy volunteers (2 males and 5 females) consumed oral rehydration solution (ORS group), mineral water (MW group), and no fluid (N group) in a crossover method before intake of enteral formula. The gastric emptying time of each enteral formula was determined by a standard gastric emptying test method using 13C excretion ratio in expired air, and changes (⊿ Tmax) in a maximum drug concentration time (Tmax) were evaluated as the primary endpoint. Results: ⊿ Tmax value of each group was compared with the Tmax of the N group. The gastric empting time was more promoted in the ORS group than in the MW group (⊿ Tmax(MW) vs. ⊿ Tmax(ORS): -5±15.0 min vs. -17.1 ±9.1 min; P=0.03). Conclusion: The results suggest that administration of oral rehydration solution before feeding enteral formula may promote gastric emptying of the enteral formula. |
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| AbstractList | Purpose: We investigated the effect of prior administration of clear fluids (oral rehydration solution and mineral water) on gastric emptying of enteral formula in healthy subjects as compared with non-consumption of clear fluids. Clear fluids were administered before feeding enteral formula. Methods: Seven healthy volunteers (2 males and 5 females) consumed oral rehydration solution (ORS group), mineral water (MW group), and no fluid (N group) in a crossover method before intake of enteral formula. The gastric emptying time of each enteral formula was determined by a standard gastric emptying test method using 13C excretion ratio in expired air, and changes (⊿ Tmax) in a maximum drug concentration time (Tmax) were evaluated as the primary endpoint. Results: ⊿ Tmax value of each group was compared with the Tmax of the N group. The gastric empting time was more promoted in the ORS group than in the MW group (⊿ Tmax(MW) vs. ⊿ Tmax(ORS): -5±15.0 min vs. -17.1 ±9.1 min; P=0.03). Conclusion: The results suggest that administration of oral rehydration solution before feeding enteral formula may promote gastric emptying of the enteral formula. Purpose: We investigated the effect of prior administration of clear fluids (oral rehydration solution and mineral water) on gastric emptying of enteral formula in healthy subjects as compared with non-consumption of clear fluids. Clear fluids were administered before feeding enteral formula.Methods: Seven healthy volunteers (2 males and 5 females) consumed oral rehydration solution (ORS group), mineral water (MW group), and no fluid (N group) in a crossover method before intake of enteral formula. The gastric emptying time of each enteral formula was determined by a standard gastric emptying test method using 13C excretion ratio in expired air, and changes (⊿ Tmax) in a maximum drug concentration time (Tmax) were evaluated as the primary endpoint.Results: ⊿ Tmax value of each group was compared with the Tmax of the N group. The gastric empting time was more promoted in the ORS group than in the MW group (⊿ Tmax(MW) vs. ⊿ Tmax(ORS): -5±15.0 min vs. -17.1 ±9.1 min; P=0.03).Conclusion: The results suggest that administration of oral rehydration solution before feeding enteral formula may promote gastric emptying of the enteral formula. 【目的】経口補水液の前投与が、経腸栄養剤の胃排出速度に与える影響を検討した。【対象および方法】健常成人ボランティア7名を対象としてクロスオーバー研究を実施した。何も投与しない群 (N群) とミネラルウォーターを投与した群 (MW群) および経口補水液を投与した群 (ORS群) における、胃排出速度を、13C呼気ガス診断を応用した胃排出能検査標準法により評価した。Primary end pointとして個々における前処置ごとに最高血中濃度到達時間 (Tmax) の変化 (⊿ Tmax) を比較した。【結果】N群のTmaxを基準にして⊿ Tmaxを比較した結果、MW群に比べORS群において経腸栄養剤の胃排出速度を促進する効果が大きかった[⊿ Tmax(MW) vs. ⊿ Tmax (ORS) :-5±15.0 min vs. -17.1 ±9.1 min ; P=0.03]。【結論】この結果から、経腸栄養剤投与前に経口補水液を投与することで、摂取された経腸栄養剤の胃排出速度が促進されると考えられた。 |
| Author | TANIGUCHI, Hideki NAKADA, Etsuko TSUJI, Tomohiro |
| Author_FL | 中田 恵津子 辻 智大 谷口 英喜 |
| Author_FL_xml | – sequence: 1 fullname: 谷口 英喜 – sequence: 2 fullname: 辻 智大 – sequence: 3 fullname: 中田 恵津子 |
| Author_xml | – sequence: 1 fullname: TANIGUCHI, Hideki organization: NST, Kanagawa Cancer Center – sequence: 1 fullname: TSUJI, Tomohiro organization: NST, Kanagawa Cancer Center – sequence: 1 fullname: NAKADA, Etsuko organization: NST, Kanagawa Cancer Center |
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| DocumentTitle_FL | 経口補水液の前投与は、経腸栄養剤の胃排出を促進する |
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| References | 9) Kreymanna KG, Bergerb MM, Deutz NEP, et al. ESPEN Guidelines on Enteral Nutrition: Intensive care. Clinical Nutrition. 25: 210-223, 2006. 15) Field M. Intestinal ion transport and the pathophysiology of diarrhea. Clin Invest 111: 931-943, 2003. 5) Taniguchi H, Sasaki T, Fujita H, et al. Preoperative fluid and electrolyte management with oral rehydration therapy. J Anesth 23: 222-229, 2009. 12) Ghoos YF, Maes BD, Geypens BJ, et al. Measurement of gastric emptying rate of solids by means of a Crrbonlabeled octanoic acid breath test. Gastroenterology 104: 1640-1647, 1993. 4) Heyland DK, Dhaliwal R, Drover JW, et al. Canadian Critical Care Clinical Practice Guidelines Committee: Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. J Parenter Enteral Nutr. 27: 355-373, 2003. 16) Celeb KK, Glass R, Bresee JS, et al. Managing acute gastroenteritis among childreNoral rehydration, maintenance, and nutritional therapy. MMWR Morb Mortal Wkly Rep. 52 (No. RR-16) : 1-16, 2003. 3) Booth CM, Heyland DK, Paterson WG. Gastrointestinal promotility drugs in the critical care setting: A systematic review of the evidence. Crit Care Med. 30: 1429-1435, 2002. 7) 中田浩二、川崎成郎、仲吉朋子ほか. 13C呼気ガス診断の臨床応用―その現状と展望―. RADIOISOTOPES56 : 629-636、2007. 17) World Health Organization. Oral rehydration salts (ORS) : a new reduced osmolarity formulation. Geneva: World Health Organization, 2002. 11) 宮澤靖. 経腸栄養. 静脈経腸栄養 22 : 455-463、2007. 8) van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Tiel FH, et al. Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med. 34: 396-402, 2006. 10) 笠間睦、田畑登美子、高野美也子ほか. 経腸栄養剤投与時の白湯注入法に関する検討. 日本醫亊新報 4520 : 60-64、2010. 13) Costill DL, Saltin B. Factors limiting gastric emptying during rest and exercise. J Appl Physiol 37: 679-863, 1974. 14) De Schepper H, Camilleri M, Cremonini F, et al. Comparison of gastric volumes in response to isocaloric liquid and mixed meals in humans. Neurogastroenterol Motil. 16: 567-573, 2004. 2) Ho KM, Dobb GJ, Webb SA. A comparison of early gastric and post-pyloric feeding in critically ill patients: a meta-analysis. Intensive Care Med. 32: 639-649, 2006. 1) McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN). J Parenter Enteral Nutr. 33: 277-315, 2009. 6) 中田浩二、青山伸郎、中川学ほか. 13C呼気試験法胃排出能検査の現状と未来 標準化に向けて. J. Smooth Muscle Res 6 : J75-J91、2002. |
| References_xml | – reference: 7) 中田浩二、川崎成郎、仲吉朋子ほか. 13C呼気ガス診断の臨床応用―その現状と展望―. RADIOISOTOPES56 : 629-636、2007. – reference: 4) Heyland DK, Dhaliwal R, Drover JW, et al. Canadian Critical Care Clinical Practice Guidelines Committee: Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. J Parenter Enteral Nutr. 27: 355-373, 2003. – reference: 5) Taniguchi H, Sasaki T, Fujita H, et al. Preoperative fluid and electrolyte management with oral rehydration therapy. J Anesth 23: 222-229, 2009. – reference: 9) Kreymanna KG, Bergerb MM, Deutz NEP, et al. ESPEN Guidelines on Enteral Nutrition: Intensive care. Clinical Nutrition. 25: 210-223, 2006. – reference: 16) Celeb KK, Glass R, Bresee JS, et al. Managing acute gastroenteritis among childreNoral rehydration, maintenance, and nutritional therapy. MMWR Morb Mortal Wkly Rep. 52 (No. RR-16) : 1-16, 2003. – reference: 6) 中田浩二、青山伸郎、中川学ほか. 13C呼気試験法胃排出能検査の現状と未来 標準化に向けて. J. Smooth Muscle Res 6 : J75-J91、2002. – reference: 8) van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Tiel FH, et al. Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med. 34: 396-402, 2006. – reference: 14) De Schepper H, Camilleri M, Cremonini F, et al. Comparison of gastric volumes in response to isocaloric liquid and mixed meals in humans. Neurogastroenterol Motil. 16: 567-573, 2004. – reference: 12) Ghoos YF, Maes BD, Geypens BJ, et al. Measurement of gastric emptying rate of solids by means of a Crrbonlabeled octanoic acid breath test. Gastroenterology 104: 1640-1647, 1993. – reference: 17) World Health Organization. Oral rehydration salts (ORS) : a new reduced osmolarity formulation. Geneva: World Health Organization, 2002. – reference: 3) Booth CM, Heyland DK, Paterson WG. Gastrointestinal promotility drugs in the critical care setting: A systematic review of the evidence. Crit Care Med. 30: 1429-1435, 2002. – reference: 11) 宮澤靖. 経腸栄養. 静脈経腸栄養 22 : 455-463、2007. – reference: 10) 笠間睦、田畑登美子、高野美也子ほか. 経腸栄養剤投与時の白湯注入法に関する検討. 日本醫亊新報 4520 : 60-64、2010. – reference: 13) Costill DL, Saltin B. Factors limiting gastric emptying during rest and exercise. J Appl Physiol 37: 679-863, 1974. – reference: 15) Field M. Intestinal ion transport and the pathophysiology of diarrhea. Clin Invest 111: 931-943, 2003. – reference: 1) McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN). J Parenter Enteral Nutr. 33: 277-315, 2009. – reference: 2) Ho KM, Dobb GJ, Webb SA. A comparison of early gastric and post-pyloric feeding in critically ill patients: a meta-analysis. Intensive Care Med. 32: 639-649, 2006. |
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| SubjectTerms | enteral nutrition gastric emptying time oral rehydration solution 経口補水液 経腸栄養 胃排出速度 |
| Title | Prior administration of oral rehydration solution promotes gastric emptying of enteral formula |
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