Prior administration of oral rehydration solution promotes gastric emptying of enteral formula

• Published in: Jomyaku Keicho Eiyo Vol. 27; no. 2; pp. 731 - 737
• Main Authors: TANIGUCHI, Hideki, TSUJI, Tomohiro, NAKADA, Etsuko
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society for Parenteral and Enteral Nutrition 2012; 日本静脈経腸栄養学会
• Subjects: enteral nutrition; gastric emptying time; oral rehydration solution; 経口補水液; 経腸栄養; 胃排出速度
• ISSN: 1344-4980; 1881-3623
• DOI: 10.11244/jjspen.27.731

Purpose: We investigated the effect of prior administration of clear fluids (oral rehydration solution and mineral water) on gastric emptying of enteral formula in healthy subjects as compared with non-consumption of clear fluids. Clear fluids were administered before feeding enteral formula. Methods: Seven healthy volunteers (2 males and 5 females) consumed oral rehydration solution (ORS group), mineral water (MW group), and no fluid (N group) in a crossover method before intake of enteral formula. The gastric emptying time of each enteral formula was determined by a standard gastric emptying test method using 13C excretion ratio in expired air, and changes (⊿ Tmax) in a maximum drug concentration time (Tmax) were evaluated as the primary endpoint. Results: ⊿ Tmax value of each group was compared with the Tmax of the N group. The gastric empting time was more promoted in the ORS group than in the MW group (⊿ Tmax(MW) vs. ⊿ Tmax(ORS): -5±15.0 min vs. -17.1 ±9.1 min; P=0.03). Conclusion: The results suggest that administration of oral rehydration solution before feeding enteral formula may promote gastric emptying of the enteral formula.