Multicenter survey on carbapenemase-producing Enterobacteriaceae in Aichi Prefecture: Epidemiological survey of carbapenemase-producing Enterobacteriaceae

• Published in: Japanese Journal of Medical Technology Vol. 68; no. 2; pp. 317 - 322
• Main Authors: HARA, Yuki, ACHIHA, Masahito, KAWACHI, Makoto, NISHIO, Mitsuru, SAKANASHI, Daisuke, YAMAGISHI, Yuka, MIKAMO, Hiroshige
• Format: Journal Article
• Language: Japanese
• Published: Japanese Association of Medical Technologists 25.04.2019
• Subjects: CPE; CRE; epidemiological survey
• ISSN: 0915-8669; 2188-5346
• DOI: 10.14932/jamt.18-53

Carbapenemase-producing Enterobacteriaceae (CPE) has become a problem worldwide and it is important to grasp the epidemiology of CPE epidemics in the region. We report on CPE surveillance at four medical facilities with the aim of grasping the situation of CPE epidemics in Aichi Prefecture. CPE detection was based on the criteria used at each institution. Of the 5,419 clinical Enterobacteriaceae isolates obtained during the period, 67 strains (1.2%) were identified, three of which produced carbapenemase, and all of these three CPEs were 3 IMP-1 strains. Of these three strains, two also produced CTX-M-type extended-spectrum β-lactamase (ESBL). An OXA-48-like strain was detected among the strains that showed susceptibility to carbapenems, and this strain also produced CTX-M-type ESBL. In this survey, four CPEs were detected, that is, 0.07% of all isolates (4/5,419). We found that CPEs have not been prevalent among clinical Enterobacteriaceae isolates in Aichi Prefecture. However, since an imported CPE isolate that demonstrates nonsusceptibility to carbapenems was detected in this area, the continuing surveillance and standardized criteria for the detection of CPE are needed to detect CPE isolates.