HLA in the patients with pusturosis palmaris et plantaris and intersterno-Costo-clavicular ossification

• Published in: Japanese Journal of Rheumatism and Joint Surgery Vol. 4; no. 2; pp. 123 - 127
• Main Authors: ISHII Yoshiaki, 河路 渡, 八木田 旭邦, 田村 晋也, 長島 正治
• Format: Journal Article
• Language: Japanese
• Published: 日本関節病学会 1985; Japanese Society for Joint Diseases
• Subjects: HLA; Two Locus Association Haplotype Frequency
• ISSN: 0287-3214; 1884-9059
• DOI: 10.11551/jsjd1982.4.123

A deviation of any HLA antigen was looked for in a total of 32 patients with pustulosis Palmaris et plantaris and Intersterno-costo-clavicular ossification. Separated lymphocytes were tested for HLA-A, B, C and DR antigens using the microlymphocytotoxity technique (8th International Workshop Method) . Antigen frequencies were compared with 300 healthy controls.HLA-Bw39 was found in 12.5% of the patients, while this antigen occurred in only 6.5% of the controls. In two locus association the frequency of Bw51 with Aw24 was 22% in patients against 2% among controls.The frequency of Bw51 with DR2 was 18.7% against only 0.92%. Thus the frequencies of Bw51 and Bw39 antigens was significant different between the patients and controls. This high incidence of these B antigens of great interest, though the difference could not be confirmed statistically.