A Study of the Therapeutic Effect of Peroral Miconazole on Oral Candidosis

• Published in: Ronen Shika Igaku Vol. 9; no. 1; pp. 26 - 33
• Main Authors: Muramatsu, Yoshikazu, Suzuki, Akira, Yamane, Ken, Muraki, Futoshi, Takashima, Iwao, Fujiyama, Naoshi, Kikutani, Takeshi, Ishida, Kanemitsu, Inaba, Shigeru
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Gerodontology 31.07.1994
• Subjects: Clinical efficacy; Oral candidosis; Peroral miconazole; The elderly
• ISSN: 0914-3866; 1884-7323
• DOI: 10.11259/jsg1987.9.26

Although Candida species is a normal oral flora, these microorganisms can cause opportunistic infection when the host's resistance is lowered leading to oral candidosis. It the present study, we demonstrated the clinical efficacy of a peroral miconazole (Florid ®oral gel) and its systemic effects by swallowing in patients with oral candidosis. A total of 14 patients with oral candidosis (8 male and 6 female, mean age 75.3 years) were the subjects inthis study. On overall evaluation performed after two-week consecutive administration with miconazole, the improvement rate of subjective symptoms, the improvement rate of objective symptoms, and the eradication rate of fungi were 76.8%, 52.8%, and 84.6%, respectively. The efficacy rate was high as 92.3%. Side effects were observed in 5 patients. Although 4 of these patients were suspected to be relaed to the investigational medicine, they were all mild or moderate. There were no changes in hematological test or biochemical test results after administration, suggesting no systemic effects by swallowing. Since the investigational medicine is a gel-formed peroral medicine, effective concentrations in lesions can be precisely maintained by applying the drug to the mucosal surface of the denture base and the mucosa, and by keeping it in the mouth for long periods. Thus it has the abvantage of ease of use not only for ambulatory patients visiting a clinic, but also for elderly patientsstaying in the hospital or at home. Considering the expected future increase in patients, both staying in the hospital and at home and those with impaired ADL in Japan, the present study indicates that the peroral miconazole is an effective medicine for the treatment of oral candidosis.