Treatment of Burn Wound with Autologous Cultured Epidermis, JACE

• Published in: Japanese Journal of Surgical Wound Care Vol. 5; no. 3; pp. 118 - 123
• Main Author: Inoie, Masukazu
• Format: Journal Article
• Language: Japanese
• Published: Japan Society for Surgical Wound Care 2014; 一般社団法人 日本創傷外科学会
• Subjects: autologous cultured epidermis; JACE; major burn; ジェイス; 自家培養表皮; 重症熱傷
• ISSN: 1884-880X
• DOI: 10.11310/jsswc.5.118

The autologous cultured epidermis, JACE, which is the first cellular product in Japan, provides a new therapy for the wound closure of major burns. Data on its safety and efficacy are being collected in post-marketing surveillance of all cases in which this product was used under national health insurance coverage since 2009. The average area of skin biopsy obtained from a patient to make the product was 8 cm2 and the average number of products grafted on a patient was 24 sheets, whose area was approximately 240-fold larger than the biopsy area. The average period that elapsed from injury to biopsy was 8.6 days, and in a few cases with delayed biopsy, contamination occurred in the process of cultivation. In the ongoing survey, the rate of cases in which an artificial dermis was used to reconstruct the dermis for graft beds was greater than that of cases in which cadaver skin was used. The use of a combination graft called the hybrid method, in which the products simultaneously cover the meshed split-thickness autograft, increased recently. It will be necessary for the efficacy of the combination graft to be verified and the procedures achieving wound healing with an artificial dermis or cadaver skin to be standardized in the treatment of burns using this product.