Biological Information-, Material - and Energy-Conversion by Iron-Containing Proteins

Iron is a metal element indispensable for life. It usually plays important roles as reaction centers of the iron-containing proteins and enzymes, and is responsible for many physiological actions, e.g., conversion of bio-materials (biosynthesis and metabolism), bio-information (signal trasnduction)...

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Published inBiomedical Research on Trace Elements Vol. 22; no. 4; pp. 50 - 58
Main Author Shiro, Yoshitsugu
Format Journal Article
LanguageEnglish
Japanese
Published Osaka Japan Society for Biomedical Research on Trace Elements 01.10.2011
Japan Science and Technology Agency
Subjects
Biosynthesis
Crystallography
Heme
Hemoprotein
Iron
Molecular mechanism
Nitric oxide
Proteins
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Summary:Iron is a metal element indispensable for life. It usually plays important roles as reaction centers of the iron-containing proteins and enzymes, and is responsible for many physiological actions, e.g., conversion of bio-materials (biosynthesis and metabolism), bio-information (signal trasnduction) and bio-energy, through the ligand binding, acid-base and reductionoxidation reactions. Our group has had much interest in iron-containing proteins and enzymes, especially heme-containing proteins and enzymes (hemoproteins and heme-enzymes). Heme is a iron-porphyrin complexes. We are studying their molecular properties on the basis of their molecular structures, which can be crystallographycally determined using the SPring-8 Beam Lines. In this article, we focus on structure-function relationship of heme-containing oxygenases, oxygensensor proteins and nitric oxide reductases.
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ISSN:0916-717X
1880-1404
DOI:10.11299/brte.22.50