A case of pituitary metastasis of lung cancer associated with panhypopituitarism and cerebral neuropathy requiring differentiation from granulomatosis with polyangiitis

• Published in: Clinical Rheumatology and Related Research Vol. 36; no. 1; pp. 56 - 63
• Main Authors: Hayashi, Chiga, Ohmura, Shin-ichiro, Miwa, Hideki, Yonezawa, Haruka, Otsuki, Yoshiro, Miyamoto, Toshiaki, Morishima, Saki, Watahiki, Motoi, Kawaji, Hiroshi, Sugimura, Yoshihisa
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society for Clinical Rheumatology and Related Research 2024; 一般社団法人 日本臨床リウマチ学会
• Subjects: central diabetes insipidus; granulomatosis with polyangiitis; panhypopituitarism; pituitary metastases; primary lung carcinoma
• ISSN: 0914-8760; 2189-0595
• DOI: 10.14961/cra.36.56

A 86-year-old woman who was diagnosed with granulomatosis polyangiitis（GPA）2 years ago developed lung adenocarcinoma（Stage IA）but she was successfully treated with radiation therapy and remained in remission. After 3 months of the radiation therapy, pituitary enlargement with panhypopituitarism developed, and the patient was treated with high-dose glucocorticoids for GPA with this lesion. However, the lesion did not improve after the treatment. Finally, she underwent pituitary biopsy and pituitary biopsy showed pituitary metastasis of lung cancer. Our case indicated that aggressive histological evaluation is very important in GPA patients with pituitary lesions.