Nitric oxide is a mediator of tachykinin NK3 receptor‐induced relaxation in rat mesenteric artery

• Published in: British journal of pharmacology Vol. 116; no. 7; pp. 2919 - 2922
• Main Authors: Mizuta, Aki, Takano, Yukio, Honda, Kenji, Saito, Ryo, Matsumoto, Takafumi, Kamiya, Hiro‐O
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.1995; Nature Publishing
• Subjects: Amino Acid Sequence; Animals; Aorta - drug effects; Biological and medical sciences; Blood vessels and receptors; endothelium; Endothelium, Vascular - metabolism; Fundamental and applied biological sciences. Psychology; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries - metabolism; Mesenteric Arteries - physiology; Mesenteric artery; Molecular Sequence Data; nitric oxide (NO); Nitric Oxide - metabolism; Nitric Oxide - physiology; NK3 receptor; Peptide Fragments - pharmacology; Rats; Rats, Wistar; Receptors, Neurokinin-3 - agonists; Receptors, Neurokinin-3 - physiology; Substance P - analogs & derivatives; Substance P - pharmacology; tachykinin; vasodilatation; Vasodilation - physiology; Vertebrates: cardiovascular system; Rat; Rodentia; Smooth muscle; In vitro; Vasodilation; Endothelium; Relaxation; Vertebrata; Mesenteric artery; Vasomotricity; Mammalia; Blood vessel; Nitrogen monoxide; NK3 receptor; Mediator; Mechanism of action
• ISSN: 0007-1188; 1476-5381
• DOI: 10.1111/j.1476-5381.1995.tb15945.x

1 The mechanism of vasodilatation induced by tachykinin peptides was studied in isolated mesenteric arteries of rats. 2 Senktide, a selective NK3 agonist, elicited potent endothelium‐dependent relaxation of arteries precontracted with phenylephrine (10‐5m), but an NK1 agonist did not. 3 A non‐peptide NK3 antagonist, SR 142801, inhibited senktide‐induced relaxation. However, a non‐peptide NK1 antagonist, CP‐96,345, and a peptide‐based NK2 antagonist, L‐659,877, had no effect on senktide‐induced relaxation. 4 Nω‐nitro‐L‐arginine (l‐NOARG), a nitric oxide synthesis inhibitor, markedly attenuated the relaxant response to senktide. 5 These results suggest that the endothelium of rat mesenteric arteries possesses tachykinin NK3 receptors, and that NK3 agonist‐induced vasodilatation is mediated by release of nitric oxide (NO) from the endothelium.