Noncoding RNAs in disease

Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with t...

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Bibliographic Details
Published inFEBS letters Vol. 592; no. 17; pp. 2884 - 2900
Main Authors Lekka, Evangelia, Hall, Jonathan
Format Journal Article
LanguageEnglish
Published England John Wiley and Sons Inc 01.09.2018
Subjects
humans
long noncoding RNA
microRNA
non-coding RNA
noncoding RNA
pathophysiology
Review
therapeutics
long noncoding RNA
microRNA
noncoding RNA
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Summary:Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of miRNAs and long noncoding RNAs in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches.
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Edited by Wilhelm Just
ISSN:0014-5793
1873-3468
1873-3468
DOI:10.1002/1873-3468.13182