SUSCEPTIBILITY OF HUMAN CULTURED CELLS TO MASON-PFIZER MONKEY VIRUS

Mason-Pfizer monkey virus (M-PMV), originally isolated from mammary carcinoma of a rhesus monkey, is infectious to various human cells in tissue culture. Human epithelioid cells (HeLa and HEp-2), fibroblastic cells (embryonic cells as well as virus-transformed embryonic RSb cells), and glial cells (...

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Published inGANN Japanese Journal of Cancer Research Vol. 69; no. 3; pp. 413 - 415
Main Authors OGURA, Hajime, OCHO, Munehiko, TANAKA, Terukazu, ODA, Takuzo
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.01.1978
Subjects
Animals
Cells, Cultured
Cultured human cell
Cytopathogenic Effect, Viral
Cytoplasm - ultrastructure
Haplorhini
Humans
KC syncytium assay
Macaca mulatta
Mason-Pfizer monkey virus
Oncogenic Viruses - pathogenicity
RNA Viruses - pathogenicity
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Summary:Mason-Pfizer monkey virus (M-PMV), originally isolated from mammary carcinoma of a rhesus monkey, is infectious to various human cells in tissue culture. Human epithelioid cells (HeLa and HEp-2), fibroblastic cells (embryonic cells as well as virus-transformed embryonic RSb cells), and glial cells (KC) have all been infected with M-PMV. Electron microscope studies have shown that all infected cells produce progeny virus. The titer of infectious M-PMV in cultures of HeLa and HEp-2 cells assayed by KC syncytium formation was 101 syncytium-forming unit (SFU) per 0.2ml. The titers for whole human embryonic cells (HEC), human embryonic lung cells (HEL), and embryonic skin Detroit-551 cells were 104 SFU/0.2ml for each, and 103 SFU/0.2ml for RSb and KC cells.
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ISSN:0016-450X
DOI:10.20772/cancersci1959.69.3_413