BIOLOGICAL FEATURES OF A TRANSPLANTABLE LEYDIG CELL TUMOR IN RAT

A Leydig cell tumor was found in an inbred W/Fu rat that had been given a thyroid destructive dose of astatine-211. It was studied by transplantation in normal and gonadectomized rats. It was autonomous when isolated. In the earlier passage, the secondary changes in tumor hosts suggested that it sec...

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Published inGANN Japanese Journal of Cancer Research Vol. 62; no. 1; pp. 41 - 48_3
Main Authors UEDA, Gaiko, CALI, Antonio, KUNII, Akira
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.01.1971
Subjects
Androgens - secretion
Animals
Astatine
Body Weight
Castration
Estrogens - secretion
Female
Hyperplasia
Hypertrophy
Leydig Cell Tumor - blood
Leydig Cell Tumor - chemically induced
Leydig Cell Tumor - pathology
Male
Mammary Glands, Animal - pathology
Mammary Neoplasms, Experimental
Neoplasm Transplantation
Organ Size
Ovary - pathology
Pituitary Gland - pathology
Prostate - pathology
Rats
Seminal Vesicles - pathology
Testicular Neoplasms
Uterus - pathology
Vagina - pathology
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Summary:A Leydig cell tumor was found in an inbred W/Fu rat that had been given a thyroid destructive dose of astatine-211. It was studied by transplantation in normal and gonadectomized rats. It was autonomous when isolated. In the earlier passage, the secondary changes in tumor hosts suggested that it secreted predominantly androgens. After further subpassages, the changes in tumor hosts suggested that it secreted both androgens and estrogens. In males, intact and gonadectomized, there was hypertrophy of prostate and seminal vesicles. In females, there was estrogenization of vaginal epithelium, glandular hyperplasia of uterine mucosa, and follicular cyst formation in ovaries. Other apparently novel observations were made with this tumor such as inhibition of castration changes in host pituitaries, lobular hypertrophy and hyperplasia of mammary glands in both sexes, and depression of spermatogenesis. This tumor failed to show morphological masculinization of renal glomeruli and of submaxillary glands, and stimulation of hemopoiesis.
ISSN:0016-450X
DOI:10.20772/cancersci1959.62.1_41