COMBINED EFFECT OF X-RAY AND BLEOMYCIN ON CULTURED MAMMALIAN CELLS

Investigations were carried out with cultured mammalian cell lines to assess the effect of combination of radiation and Bleomycin. When cells were treated with the antibiotic before and during exposure to X-rays, a slight potentiating effect was consistently found. The magnitude of potentiation of t...

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Bibliographic Details
Published inGANN Japanese Journal of Cancer Research Vol. 66; no. 6; pp. 701 - 703
Main Authors TERASIMA, Toyozo, TAKABE, Yosinobu, YASUKAWA, Mieko
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.01.1975
Subjects
Animals
Bleomycin
Bleomycin - pharmacology
Cell Survival - drug effects
Cell Survival - radiation effects
Combined effect
Cultured mammalian cells
HeLa Cells
L Cells (Cell Line)
Radiation Effects
X-ray
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Summary:Investigations were carried out with cultured mammalian cell lines to assess the effect of combination of radiation and Bleomycin. When cells were treated with the antibiotic before and during exposure to X-rays, a slight potentiating effect was consistently found. The magnitude of potentiation of the radiation effect appeared to depend on the concentration of Bleomycin. When the cells were treated pulsewise at various periods after irradiation, the potentiating effect was found only during the first 2hr. Simultaneous application of X-rays and Bleomycin provided the greatest effect.
ISSN:0016-450X
DOI:10.20772/cancersci1959.66.6_701