EFFECT OF VITAMIN A ACETATE ON URINARY BLADDER CARCINOGENESIS INDUCED BY N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE IN RATS

The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was determined in male Wistar rats. Vitamin A acetate at the dose administered induced no changes in the urinary bladder or other organs when administered without the carcinogen. Ho...

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Published inGANN Japanese Journal of Cancer Research Vol. 69; no. 6; pp. 845 - 848
Main Authors MIYATA, Yukitada, TSUDA, Hiroyuki, MATAYOSHI-MIYASATO, Kinuko, FUKUSHIMA, Shoji, MURASAKI, Gen'i, OGISO, Tadashi, ITO, Nobuyuki
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.01.1978
Subjects
Animals
Butylhydroxybutylnitrosamine
Carcinoma, Transitional Cell - chemically induced
Carcinoma, Transitional Cell - prevention & control
Inhibiting effect
Male
N-Butyl-N-(4-hydroxybutyl)nitrosamine
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - prevention & control
Nitrosamines
Papilloma - prevention & control
Rats
Urinary Bladder - pathology
Urinary bladder carcinogenesis
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - prevention & control
Vitamin A - administration & dosage
Vitamin A acetate
Wistar rat
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Abstract The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was determined in male Wistar rats. Vitamin A acetate at the dose administered induced no changes in the urinary bladder or other organs when administered without the carcinogen. However, hypervitaminosis A inhibited keratinization and squamous metaplasia in bladder lesions induced by BBN, and the incidence of transitional cell carcinoma and papilloma of the urinary bladder was significantly reduced at a dose greater than 100IU/g diet (P<0.02). The present experiment suggests that for the urinary bladder epithelium of rats hypervitaminosis A reduced susceptibility to the tumorigenicity of BBN.
AbstractList The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was determined in male Wistar rats. Vitamin A acetate at the dose administered induced no changes in the urinary bladder or other organs when administered without the carcinogen. However, hypervitaminosis A inhibited keratinization and squamous metaplasia in bladder lesions induced by BBN, and the incidence of transitional cell carcinoma and papilloma of the urinary bladder was significantly reduced at a dose greater than 100 IU/g diet (P less than 0.02). The present experiment suggests that for the urinary bladder epithelium of rats hypervitaminosis A reduced susceptibility to the tumorigenicity of BBN.
The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was determined in male Wistar rats. Vitamin A acetate at the dose administered induced no changes in the urinary bladder or other organs when administered without the carcinogen. However, hypervitaminosis A inhibited keratinization and squamous metaplasia in bladder lesions induced by BBN, and the incidence of transitional cell carcinoma and papilloma of the urinary bladder was significantly reduced at a dose greater than 100IU/g diet (P<0.02). The present experiment suggests that for the urinary bladder epithelium of rats hypervitaminosis A reduced susceptibility to the tumorigenicity of BBN.
Author OGISO, Tadashi
MATAYOSHI-MIYASATO, Kinuko
MURASAKI, Gen'i
FUKUSHIMA, Shoji
MIYATA, Yukitada
TSUDA, Hiroyuki
ITO, Nobuyuki
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Snippet The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was determined in male Wistar rats....
The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was determined in male Wistar rats....
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SubjectTerms Animals
Butylhydroxybutylnitrosamine
Carcinoma, Transitional Cell - chemically induced
Carcinoma, Transitional Cell - prevention & control
Inhibiting effect
Male
N-Butyl-N-(4-hydroxybutyl)nitrosamine
Neoplasms, Experimental - chemically induced
Neoplasms, Experimental - prevention & control
Nitrosamines
Papilloma - prevention & control
Rats
Urinary Bladder - pathology
Urinary bladder carcinogenesis
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - prevention & control
Vitamin A - administration & dosage
Vitamin A acetate
Wistar rat
Title EFFECT OF VITAMIN A ACETATE ON URINARY BLADDER CARCINOGENESIS INDUCED BY N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE IN RATS
URI https://www.jstage.jst.go.jp/article/cancersci1959/69/6/69_6_845/_article/-char/en
https://www.ncbi.nlm.nih.gov/pubmed/750276
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