EFFECT OF VITAMIN A ACETATE ON URINARY BLADDER CARCINOGENESIS INDUCED BY N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE IN RATS

• Published in: GANN Japanese Journal of Cancer Research Vol. 69; no. 6; pp. 845 - 848
• Main Authors: MIYATA, Yukitada, TSUDA, Hiroyuki, MATAYOSHI-MIYASATO, Kinuko, FUKUSHIMA, Shoji, MURASAKI, Gen'i, OGISO, Tadashi, ITO, Nobuyuki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Cancer Association 01.01.1978
• Subjects: Animals; Butylhydroxybutylnitrosamine; Carcinoma, Transitional Cell - chemically induced; Carcinoma, Transitional Cell - prevention & control; Inhibiting effect; Male; N-Butyl-N-(4-hydroxybutyl)nitrosamine; Neoplasms, Experimental - chemically induced; Neoplasms, Experimental - prevention & control; Nitrosamines; Papilloma - prevention & control; Rats; Urinary Bladder - pathology; Urinary bladder carcinogenesis; Urinary Bladder Neoplasms - chemically induced; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - prevention & control; Vitamin A - administration & dosage; Vitamin A acetate; Wistar rat
• ISSN: 0016-450X
• DOI: 10.20772/cancersci1959.69.6_845

The effect of vitamin A acetate on the urinary bladder carcinogenicity of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was determined in male Wistar rats. Vitamin A acetate at the dose administered induced no changes in the urinary bladder or other organs when administered without the carcinogen. However, hypervitaminosis A inhibited keratinization and squamous metaplasia in bladder lesions induced by BBN, and the incidence of transitional cell carcinoma and papilloma of the urinary bladder was significantly reduced at a dose greater than 100IU/g diet (P<0.02). The present experiment suggests that for the urinary bladder epithelium of rats hypervitaminosis A reduced susceptibility to the tumorigenicity of BBN.